Hormonal regulation of NK cell cytotoxic activity
- 作者: Shirshev S.V.1, Nekrasova I.V.1, Gorbunova O.L.1, Orlova E.G.1
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隶属关系:
- Institute of Ecology and Genetics of Microorganisms, Ural Division
- 期: 卷 472, 编号 1 (2017)
- 页面: 28-30
- 栏目: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153978
- DOI: https://doi.org/10.1134/S0012496617010021
- ID: 153978
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详细
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
作者简介
S. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Division
编辑信件的主要联系方式.
Email: shirshev@iegm.ru
俄罗斯联邦, Perm, 614081
I. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
俄罗斯联邦, Perm, 614081
O. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
俄罗斯联邦, Perm, 614081
E. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
俄罗斯联邦, Perm, 614081
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