HCV coinfection of the HIV-infected patients with discordant CD4+ T-cell response to antiretroviral therapy leads to intense systemic inflammation
- Authors: Shmagel K.V.1, Korolevskaya L.B.1, Saidakova E.V.1, Shmagel N.G.2, Chereshnev V.A.1,3, Margolis L.4, Anthony D.5, Lederman M.5
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Perm Regional Center for Protection against AIDS and Infectious Diseases
- Institute of Immunology and Physiology, Ural Branch
- National Institute of Child Health and Human Development
- Case Western Reserve University
- Issue: Vol 477, No 1 (2017)
- Pages: 244-247
- Section: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/154179
- DOI: https://doi.org/10.1134/S0012496617060047
- ID: 154179
Cite item
Abstract
The level of proinflammatory markers was assessed in HIV-infected patients that were coinfected with hepatitis C virus (HCV) and had failed to restore the CD4+ T cell counts (immunological nonresponders, INR) during the antiretroviral therapy (ART). Among four patient groups (HIV+HCV– and HIV+HCV+ subjects with the concordant response to ART; HIV+HCV– and HIV+HCV+ subjects that were INR), the greatest systemic inflammation was in the latter group. The maximum difference was between the subjects HIV+HCV–INR and HIV+HCV+ INR: the blood of coinfected patients contained significantly higher concentrations of the IP-10, sCD163, sTNF-RI, and sTNF-RII and of bacterial lipopolysaccharide. Systemic inflammation in HIV/HCV coinfected patients with the discordant response to ART is probably caused by a breach of hepatic barrier for the intestine products.
About the authors
K. V. Shmagel
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Author for correspondence.
Email: shmagel@iegm.ru
Russian Federation, Perm
L. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shmagel@iegm.ru
Russian Federation, Perm
E. V. Saidakova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: shmagel@iegm.ru
Russian Federation, Perm
N. G. Shmagel
Perm Regional Center for Protection against AIDS and Infectious Diseases
Email: shmagel@iegm.ru
Russian Federation, Perm
V. A. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Institute of Immunology and Physiology, Ural Branch
Email: shmagel@iegm.ru
Russian Federation, Perm; Yekaterinburg
L. Margolis
National Institute of Child Health and Human Development
Email: shmagel@iegm.ru
United States, Bethesda, MD
D. Anthony
Case Western Reserve University
Email: shmagel@iegm.ru
United States, Cleveland, OH
M. Lederman
Case Western Reserve University
Email: shmagel@iegm.ru
United States, Cleveland, OH
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