HCV coinfection of the HIV-infected patients with discordant CD4+ T-cell response to antiretroviral therapy leads to intense systemic inflammation


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription Access

Abstract

The level of proinflammatory markers was assessed in HIV-infected patients that were coinfected with hepatitis C virus (HCV) and had failed to restore the CD4+ T cell counts (immunological nonresponders, INR) during the antiretroviral therapy (ART). Among four patient groups (HIV+HCV and HIV+HCV+ subjects with the concordant response to ART; HIV+HCV and HIV+HCV+ subjects that were INR), the greatest systemic inflammation was in the latter group. The maximum difference was between the subjects HIV+HCVINR and HIV+HCV+ INR: the blood of coinfected patients contained significantly higher concentrations of the IP-10, sCD163, sTNF-RI, and sTNF-RII and of bacterial lipopolysaccharide. Systemic inflammation in HIV/HCV coinfected patients with the discordant response to ART is probably caused by a breach of hepatic barrier for the intestine products.

About the authors

K. V. Shmagel

Institute of Ecology and Genetics of Microorganisms, Ural Branch

Author for correspondence.
Email: shmagel@iegm.ru
Russian Federation, Perm

L. B. Korolevskaya

Institute of Ecology and Genetics of Microorganisms, Ural Branch

Email: shmagel@iegm.ru
Russian Federation, Perm

E. V. Saidakova

Institute of Ecology and Genetics of Microorganisms, Ural Branch

Email: shmagel@iegm.ru
Russian Federation, Perm

N. G. Shmagel

Perm Regional Center for Protection against AIDS and Infectious Diseases

Email: shmagel@iegm.ru
Russian Federation, Perm

V. A. Chereshnev

Institute of Ecology and Genetics of Microorganisms, Ural Branch; Institute of Immunology and Physiology, Ural Branch

Email: shmagel@iegm.ru
Russian Federation, Perm; Yekaterinburg

L. Margolis

National Institute of Child Health and Human Development

Email: shmagel@iegm.ru
United States, Bethesda, MD

D. Anthony

Case Western Reserve University

Email: shmagel@iegm.ru
United States, Cleveland, OH

M. Lederman

Case Western Reserve University

Email: shmagel@iegm.ru
United States, Cleveland, OH

Supplementary files

Supplementary Files
Action
1. JATS XML

Copyright (c) 2017 Pleiades Publishing, Ltd.