Email this article Role of α-fetoprotein in differentiation of regulatory T lymphocytes
- Authors: Chereshnev V.A.1,2,3, Timganova V.P.1, Zamorina S.A.1,2, Bochkova M.S.1, Khramtsov P.V.1,2, Kropaneva M.D.2, Raev M.B.1,2,3
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch
- Perm State National Research University
- Ural Federal University
- Issue: Vol 477, No 1 (2017)
- Pages: 248-251
- Section: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/154183
- DOI: https://doi.org/10.1134/S0012496617060084
- ID: 154183
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Abstract
The effect of native α-fetoprotein (AFP) on the expression of T-regulatory lymphocyte (Treg) markers by activated CD4+ lymphocytes with different proliferative status was studied. α-Fetoprotein did not affect the ratio of proliferating and non-proliferating activated CD4+ cells. In the study of Treg differentiation, it was found that AFP at concentrations of 50 and 100 μg/mL significantly inhibited the number of nonproliferating CD4+FOXP3+ and CD4+FOXP3+HELIOS+ lymphocytes without affecting the expression of Treg markers by proliferating CD4+ lymphocytes.
About the authors
V. A. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm; Yekaterinburg
V. P. Timganova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Author for correspondence.
Email: timganovavp@gmail.com
Russian Federation, Perm
S. A. Zamorina
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm
M. S. Bochkova
Institute of Ecology and Genetics of Microorganisms, Ural Branch
Email: timganovavp@gmail.com
Russian Federation, Perm
P. V. Khramtsov
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm
M. D. Kropaneva
Perm State National Research University
Email: timganovavp@gmail.com
Russian Federation, Perm
M. B. Raev
Institute of Ecology and Genetics of Microorganisms, Ural Branch; Perm State National Research University; Ural Federal University
Email: timganovavp@gmail.com
Russian Federation, Perm; Perm; Yekaterinburg
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