Comparative study of Y3+ effect on calcium-dependent processes in frog cardiac muscle and mitochondria of rat cardiomyocytes
- 作者: Korotkov S.M.1, Sobol’ K.V.1, Shemarova I.V.1, Furaev V.V.1, Nesterov V.P.1
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隶属关系:
- Sechenov Institute of Evolutionary Physiology and Biochemistry
- 期: 卷 52, 编号 3 (2016)
- 页面: 196-203
- 栏目: Comparative and Ontogenic Biochemistry
- URL: https://journal-vniispk.ru/0022-0930/article/view/159030
- DOI: https://doi.org/10.1134/S0022093016030029
- ID: 159030
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详细
Inotropic effects of yttrium acetate (Y3+) on contractions of myocardium preparations of the frog Rana ridibunda, as well as on respiration and the inner membrane potential (ΔΨmito) of isolated rat heart mitochondria were studied. 2 mM yttrium in Ringer solution was found to significantly reduce the amplitude of myocardium contractions, evoked by electric stimulation, and increase the half-relaxation time (n = 5). In experiments with Ca2+, Y3+ decreased the Ca2+-dependent basal respiration rate in rat heart mitochondria, energized by glutamate and malate, impeded the reduction in respiration of these mitochondria operating in state 3 after Chance or uncoupled by 2,4-dinitrophenol, and inhibited a Ca2+-induced reduction in their inner membrane potential. The data obtained are important for better understanding the mechanism underlying Y3+ effects on the myocardial Ca2+-dependent processes. Possible mechanisms of the negative inotropic effect of Y3+ on myocardium and its influence on the Ca2+-dependent processes in rat mitochondria are discussed.
作者简介
S. Korotkov
Sechenov Institute of Evolutionary Physiology and Biochemistry
编辑信件的主要联系方式.
Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg
K. Sobol’
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg
I. Shemarova
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg
V. Furaev
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg
V. Nesterov
Sechenov Institute of Evolutionary Physiology and Biochemistry
Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg
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