Comparative study of Y3+ effect on calcium-dependent processes in frog cardiac muscle and mitochondria of rat cardiomyocytes


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Inotropic effects of yttrium acetate (Y3+) on contractions of myocardium preparations of the frog Rana ridibunda, as well as on respiration and the inner membrane potential (ΔΨmito) of isolated rat heart mitochondria were studied. 2 mM yttrium in Ringer solution was found to significantly reduce the amplitude of myocardium contractions, evoked by electric stimulation, and increase the half-relaxation time (n = 5). In experiments with Ca2+, Y3+ decreased the Ca2+-dependent basal respiration rate in rat heart mitochondria, energized by glutamate and malate, impeded the reduction in respiration of these mitochondria operating in state 3 after Chance or uncoupled by 2,4-dinitrophenol, and inhibited a Ca2+-induced reduction in their inner membrane potential. The data obtained are important for better understanding the mechanism underlying Y3+ effects on the myocardial Ca2+-dependent processes. Possible mechanisms of the negative inotropic effect of Y3+ on myocardium and its influence on the Ca2+-dependent processes in rat mitochondria are discussed.

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S. Korotkov

Sechenov Institute of Evolutionary Physiology and Biochemistry

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Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg

K. Sobol’

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg

I. Shemarova

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg

V. Furaev

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg

V. Nesterov

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: korotkov@SK1645.spb.edu
俄罗斯联邦, St. Petersburg

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