Effects of exenatide on glycemia and renal water and ion excretion differ in frogs and rats


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Abstract

The aim of this study was to compare the effects of exenatide, a glucagon-like peptide-1 (GLP-1) mimetic, on glucose and water–salt homeostasis in animals with different levels of renal proximal tubular reabsorption, rats (Rattus norvegicus) and frogs (Rana temporaria). Following the glucose tolerance test, in rats exenatide promoted fast recovery of normoglycemia, whereas in frogs it delayed this process. In water-loaded rats, exenatide augmented solute-free water clearance and enhanced natriuresis in furosemide-treated animals. In frogs, exenatide did not alter the urinary flow rate, urinary sodium excretion and solute-free water clearance under water diuresis and furosemide treatment. It is suggested that the involvement of GLP-1 in regulation of water–salt homeostasis in mammals was preceded by a key evolutionary transformation, the increase in the glomerular filtration rate and proximal tubular reabsorption.

About the authors

A. V. Kutina

Sechenov Institute of Evolutionary Physiology and Biochemistry

Author for correspondence.
Email: kutina_anna@mail.ru
Russian Federation, St. Petersburg

A. S. Marina

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: kutina_anna@mail.ru
Russian Federation, St. Petersburg

Yu. V. Natochin

Sechenov Institute of Evolutionary Physiology and Biochemistry

Email: kutina_anna@mail.ru
Russian Federation, St. Petersburg

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