New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure

N. E. Basova; B. N. Kormilitsyn; A. Yu. Perchenok; E. V. Rozengart; V. S. Saakov; A. A. Suvorov

doi:10.1134/S0022093018010039

New Acylate and Thioacylate Effectors of Mammalian Cholinesterases Based on Cyclic Ammonium Alcohols Containing Elements of the Anabasine Structure

Authors: Basova N.E.¹, Kormilitsyn B.N.¹, Perchenok A.Y.¹, Rozengart E.V.¹, Saakov V.S.¹, Suvorov A.A.¹
Affiliations:
1. Sechenov Institute of Evolutionary Physiology and Biochemistry
Issue: Vol 54, No 1 (2018)
Pages: 22-29
Section: Comparative and Ontogenic Biochemistry
URL: https://journal-vniispk.ru/0022-0930/article/view/159416
DOI: https://doi.org/10.1134/S0022093018010039
ID: 159416

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Abstract

We report a pioneering analysis of the interaction between mammalian cholinesterases and 36 acylates and thioacylates of ammonium alcohols with different structure of an alkyl chain between ammonium and etheric atoms and with different structure of a cyclic ammonium group. Among these ethers, which were both substrates and reversible inhibitors of erythrocyte cholinesterase and serum butyrylcholinesterase, specific effectors of both enzymes were identified.