Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development
- Authors: Panova I.G.1, Bezzubenko Y.V.2, Tatikolov A.S.3, Poltavtseva R.A.2, Ivanets T.Y.2, Sukhikh G.T.2
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Affiliations:
- Koltsov Institute of Developmental Biology
- Kulakov Research Center of Obstetrics, Gynecology and Perinatology
- Emanuel Institute of Biochemical Physics
- Issue: Vol 54, No 2 (2018)
- Pages: 119-122
- Section: Comparative and Ontogenic Biochemistry
- URL: https://journal-vniispk.ru/0022-0930/article/view/159449
- DOI: https://doi.org/10.1134/S0022093018020047
- ID: 159449
Cite item
Abstract
The presence of alpha-fetoprotein (AFP) was shown in the retina and lens of the human fetal eye at different stages of prenatal development. PCR analysis revealed AFP mRNA neither in the retina nor in the lens, whereas in the fetal liver (control) AFP mRNA was found to be expressed. The data obtained indicate that AFP is not synthesized in retinal and lens cells of the human fetal eye but is imported from elsewhere to be taken up by these cells. The presence of AFP in the retina and lens implies its involvement in early morphogenesis and differentiation of these ocular tissues during prenatal human development.
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About the authors
I. G. Panova
Koltsov Institute of Developmental Biology
Author for correspondence.
Email: pinag@mail.ru
Russian Federation, Moscow
Yu. V. Bezzubenko
Kulakov Research Center of Obstetrics, Gynecology and Perinatology
Email: pinag@mail.ru
Russian Federation, Moscow
A. S. Tatikolov
Emanuel Institute of Biochemical Physics
Email: pinag@mail.ru
Russian Federation, Moscow
R. A. Poltavtseva
Kulakov Research Center of Obstetrics, Gynecology and Perinatology
Email: pinag@mail.ru
Russian Federation, Moscow
T. Yu. Ivanets
Kulakov Research Center of Obstetrics, Gynecology and Perinatology
Email: pinag@mail.ru
Russian Federation, Moscow
G. T. Sukhikh
Kulakov Research Center of Obstetrics, Gynecology and Perinatology
Email: pinag@mail.ru
Russian Federation, Moscow
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