Alpha-Fetoprotein in Retina and Lens of the Human Eye at Early Stages of Prenatal Development


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Abstract

The presence of alpha-fetoprotein (AFP) was shown in the retina and lens of the human fetal eye at different stages of prenatal development. PCR analysis revealed AFP mRNA neither in the retina nor in the lens, whereas in the fetal liver (control) AFP mRNA was found to be expressed. The data obtained indicate that AFP is not synthesized in retinal and lens cells of the human fetal eye but is imported from elsewhere to be taken up by these cells. The presence of AFP in the retina and lens implies its involvement in early morphogenesis and differentiation of these ocular tissues during prenatal human development.

About the authors

I. G. Panova

Koltsov Institute of Developmental Biology

Author for correspondence.
Email: pinag@mail.ru
Russian Federation, Moscow

Yu. V. Bezzubenko

Kulakov Research Center of Obstetrics, Gynecology and Perinatology

Email: pinag@mail.ru
Russian Federation, Moscow

A. S. Tatikolov

Emanuel Institute of Biochemical Physics

Email: pinag@mail.ru
Russian Federation, Moscow

R. A. Poltavtseva

Kulakov Research Center of Obstetrics, Gynecology and Perinatology

Email: pinag@mail.ru
Russian Federation, Moscow

T. Yu. Ivanets

Kulakov Research Center of Obstetrics, Gynecology and Perinatology

Email: pinag@mail.ru
Russian Federation, Moscow

G. T. Sukhikh

Kulakov Research Center of Obstetrics, Gynecology and Perinatology

Email: pinag@mail.ru
Russian Federation, Moscow

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