Effect of the Eubothrium rugosum (Cestoda) Extract on Intestinal Proteolytic Activity in Various Fish Species
- Authors: Izvekova G.I.1, Frolova T.V.1, Izvekov E.I.1, Parshukov A.N.2, Solovyev M.M.3,4
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Affiliations:
- Papanin Institute for Biology of Inland Waters
- Institute of Biology, Karelian Research Center
- Institute of Animal Systematics and Ecology
- Tomsk State University
- Issue: Vol 55, No 1 (2019)
- Pages: 47-54
- Section: Comparative and Ontogenic Biochemistry
- URL: https://journal-vniispk.ru/0022-0930/article/view/159666
- DOI: https://doi.org/10.1134/S002209301901006X
- ID: 159666
Cite item
Abstract
The extract of the fish tapeworm Eubothrium rugosum was found to inhibit activity of intestinal proteases in its host, the burbot. A decrease in proteolytic activity of the intestinal mucosa, when using the E. rugosum extract as an inhibitor, is comparable with that of a serine protease inhibitor PMSF. This implies that the tapeworm-produced inhibitor inactivates major intestinal serine proteases, trypsin and chymotrypsin. The tapeworm extract was also demonstrated to inhibit proteolytic activity in the intestinal mucosa of the two other fish species, zope and bream. Using the Gini index, it was found that the distribution of percent inhibition levels shows some nonuniformity across the given set of species. Namely, the tapeworm extract exerts a more selective inhibitory effect on intestinal proteases in different fish species as compared to PMSF. This indicates a partial though quite explicit species-specific selectivity of the tapeworm-produced inhibitor toward the host’s proteolytic activity which may contribute to the formation of specific host-parasite interrelationships.
Keywords
About the authors
G. I. Izvekova
Papanin Institute for Biology of Inland Waters
Email: izvekov@ibiw.yaroslavl.ru
Russian Federation, Borok
T. V. Frolova
Papanin Institute for Biology of Inland Waters
Email: izvekov@ibiw.yaroslavl.ru
Russian Federation, Borok
E. I. Izvekov
Papanin Institute for Biology of Inland Waters
Author for correspondence.
Email: izvekov@ibiw.yaroslavl.ru
Russian Federation, Borok
A. N. Parshukov
Institute of Biology, Karelian Research Center
Email: izvekov@ibiw.yaroslavl.ru
Russian Federation, Petrozavodsk
M. M. Solovyev
Institute of Animal Systematics and Ecology; Tomsk State University
Email: izvekov@ibiw.yaroslavl.ru
Russian Federation, Novosibirsk; Tomsk
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