Immunolocalization of Cystathionine β-Synthase, Cystathionine γ-Lyase, Heme Oxygenase-2 and Nitric Oxide Synthase in the Human Fetal Retina in Different Gestational Trimesters
- 作者: Matveeva N.Y.1, Kalinichenko S.G.1, Kotsyuba E.P.2, Kovaleva I.V.1, Edranov S.S.1, Matveev Y.A.1
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隶属关系:
- Pacific State Medical University
- A. V. Zhirmunsky Institute of Marine Biology
- 期: 卷 55, 编号 3 (2019)
- 页面: 222-230
- 栏目: Morphological Basics for Evolution of Functions
- URL: https://journal-vniispk.ru/0022-0930/article/view/159741
- DOI: https://doi.org/10.1134/S0022093019030074
- ID: 159741
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详细
The endogenous gaseous transmitters (GTs) —nitrogen oxide (NO), carbon monoxide (CO) and hydrogen sulfide (H2S)—make up a special neuromodulatory system which mediates the development, maturation and plastic modification of nervous centers. We addressed immunolocalization of the key enzymes of GT synthesis, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), heme oxygenase-2 (HO-2) and constitutive NO synthase (nNOS), at different ontogenetic stages of the human fetal retina. CBS, CSE and HO-2 were found to be expressed in photoreceptor, bipolar and amacrine neurons, the number of which increases in the first and decreases in the third trimesters of gestation. The number of nNOS-immunopositive amacrine and ganglion neurons demonstrates inverse dynamics with maximal values in the third trimester. Uneven distribution patterns of the marker enzymes are discussed in the light of the modulatory function of GTs in neurogenesis of the human retina and their involvement in cytoprotective mechanisms.
作者简介
N. Matveeva
Pacific State Medical University
编辑信件的主要联系方式.
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
S. Kalinichenko
Pacific State Medical University
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
E. Kotsyuba
A. V. Zhirmunsky Institute of Marine Biology
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
I. Kovaleva
Pacific State Medical University
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
S. Edranov
Pacific State Medical University
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
Yu. Matveev
Pacific State Medical University
Email: nymatveeva@mail.ru
俄罗斯联邦, Vladivostok
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