Email this article HIV Restriction Factors and Their Ambiguous Role during Infection
- Authors: Zotova A.A.1,2, Atemasova A.A.1, Filatov A.V.3, Mazurov D.V.2,3
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Affiliations:
- Moscow State University, Faculty of Biology
- Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences
- National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
- Issue: Vol 53, No 2 (2019)
- Pages: 212-226
- Section: Reviews
- URL: https://journal-vniispk.ru/0026-8933/article/view/163862
- DOI: https://doi.org/10.1134/S0026893319020171
- ID: 163862
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Abstract
Currently, more than 37 million individuals worldwide are infected with the human immunodeficiency virus (HIV). Antiretroviral therapy may control the viral infection but is incapable of eradicating it. It is important to understand how cells respond to HIV-1 infection and what cellular factors are involved in this process to develop novel classes of antiviral drugs. This review summarizes the current understanding of the HIV restriction mechanism. We discuss the ambiguous role of HIV restriction factors in viral infection and counteraction mediated by HIV-1 accessory proteins.
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About the authors
A. A. Zotova
Moscow State University, Faculty of Biology; Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences
Author for correspondence.
Email: ashunaeva@gmail.com
Russian Federation, Moscow, 119991; Moscow, 119334
A. A. Atemasova
Moscow State University, Faculty of Biology
Email: ashunaeva@gmail.com
Russian Federation, Moscow, 119991
A. V. Filatov
National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
Email: ashunaeva@gmail.com
Russian Federation, Moscow, 115478
D. V. Mazurov
Cell and Gene Technology Group, Institute of Gene Biology, Russian Academy of Sciences; National Research Center—Institute of Immunology of Federal Medical-Biological Agency of Russia
Email: ashunaeva@gmail.com
Russian Federation, Moscow, 119334; Moscow, 115478
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