Email this article Monitoring of 24-h ECG and glucose level for detection of relations between glycemia and QT interval duration in type 1 diabetics
- Authors: Laptev DN, Ryabykina GV, Seid-Guseynov AA, Laptev DN, Ryabykina GV, Seid-Guseinov AA
- Issue: Vol 81, No 4 (2009)
- Pages: 28-33
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/30298
- ID: 30298
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Abstract
Aim. To study correlations between glycemia and duration of ventricular repolarization in children and adolescents with type 1 diabetes mellitus (DM).
Material and methods. Parallel monitoring of ECG and glycemia was conducted in 43 type 1 MD patients (age 7-17 years, 12.8 ± 2.7) and 37 healthy children and adolescents.
Results. Glycemia under 3 mmol/l and over 19 mmol/l is associated with significantly longer QTc interval compare to other blood glucose levels (437 ms and 447 ms versus 430 ms, p < 0.01). Also, in these glycemia values QTc interval duration over 440 ms (46 and 62% versus 33%; p<0.01) becomes more frequent. In healthy children and adolescents mean duration and frequency of a longer QTc interval were significantly less than in diabetic patients irrespective of glycemia degree in patients with type 1 DM (p < 0.01). A moderate correlation was found between a daily insulin dose and QTc duration (correlation coefficient 0.35, p = 0.02).
Conclusion. Glycemia under 3 mmol/l and over 19 mmol/l can prolong QT interval and, therefore, raise the risk of cardiovascular death in patients with type 1 DM.
Material and methods. Parallel monitoring of ECG and glycemia was conducted in 43 type 1 MD patients (age 7-17 years, 12.8 ± 2.7) and 37 healthy children and adolescents.
Results. Glycemia under 3 mmol/l and over 19 mmol/l is associated with significantly longer QTc interval compare to other blood glucose levels (437 ms and 447 ms versus 430 ms, p < 0.01). Also, in these glycemia values QTc interval duration over 440 ms (46 and 62% versus 33%; p<0.01) becomes more frequent. In healthy children and adolescents mean duration and frequency of a longer QTc interval were significantly less than in diabetic patients irrespective of glycemia degree in patients with type 1 DM (p < 0.01). A moderate correlation was found between a daily insulin dose and QTc duration (correlation coefficient 0.35, p = 0.02).
Conclusion. Glycemia under 3 mmol/l and over 19 mmol/l can prolong QT interval and, therefore, raise the risk of cardiovascular death in patients with type 1 DM.
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About the authors
D N Laptev
G V Ryabykina
A A Seid-Guseynov
D N Laptev
G V Ryabykina
A A Seid-Guseinov
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