电邮这篇文章 The role of atherosclerosis risk factors in development of coronary artery disease in young men
- 作者: Ezhov MV, Afanas'eva OI, Kambegova AA, Afanas'eva MI, Trukhacheva EP, Naumov VG, Pokrovskiy SN, Ezhov MV, Afanasyeva OI, Kambegova AA, Afanasyeva MI, Trukhacheva EP, Naumov VG, Pokrovsky SN
- 期: 卷 81, 编号 5 (2009)
- 页面: 50-53
- 栏目: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/30341
- ID: 30341
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Material and methods. A total of 235 males aged 28-45 years were examined with coronarography which detected more than 50% narrowing in one or several major CA in 200 patients (the study group with coronary artery disease), 35 males without coronary stenosis served control. Atherosclerosis risk factors, serum lipids, lipoprotein(a), fibrinogen, C-reactive protein (CRP) were assessed.
Results. Smoking and hyperlipidemia (HLE) were registered in the study group more frequently. The level of lipoprotein(a) above 30 mg/dl was recorded in 98 (49%) and 7 (20%) patients of the study and control group, respectively (p = 0.001). As shown by a correlation analysis, the number of affected CA was associated with smoking (r = 0.2; p < 0.001), HLE (r = 0.23; p < 0.001), concentration of total cholesterol (r = 0.23; p < 0.0.001), lipoprotein (a) (r = 0.26; p < 0.001) and CRP (r = 0.26; p < 0.05). The level of lipoprotein(a) in patients with myocardial infarction and occluded artery was significantly higher than in patients without myocardial infarction and non-occlusive CA affection.
Conclusion. The presence and severity of coronary atherosclerosis in young men with coronary artery disease are associated with smoking, HLE and high concentration of lipoprotein (a).
作者简介
M Ezhov
O Afanas'eva
A Kambegova
M Afanas'eva
E Trukhacheva
V Naumov
S Pokrovskiy
M Ezhov
O Afanasyeva
A Kambegova
M Afanasyeva
E Trukhacheva
V Naumov
S Pokrovsky
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