Email this article The value of changes in CD8+CD28+ and CD4+CD28+ cells in patients with HIV infection concurrent with tuberculosis during treatment
- Authors: Popova AA1, Kravchenko AV1, Kozhevnikova GM2, Zimina VN3
-
Affiliations:
- Центральный НИИ эпидемиологии Роспотребнадзора
- Российский университет дружбы народов, Москва
- Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения Москвы
- Issue: Vol 85, No 11 (2013)
- Pages: 54-57
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/31379
- ID: 31379
Cite item
Full Text
Abstract
AIM: To study the proportion of CD8+CD28+ and CD4+CD28+ cells among the CD8+ and CD4+ lymphocytes and the changes in these indicators in patients with HIV infection/tuberculosis (HIV/TB) versus those with HIV infection and those with TB/MATERIAL AND METHODS: One hundred and six persons were examined and included into 4 study groups: 1) 39 patients with concomitant HIV/TB; 2) 25 patients with HIV monoinfection without TB who had not previously received antiretroviral therapy; 3) 17 patients with TB without HIV infection; 4) 25 healthy individuals (a control group)/RESULTS: CD28 expression was found to be much more reduced on the CD8 lymphocytes than that on the CD4 ones. This is likely to be due to earlier CD8 lymphocyte dysfunction in both the patients with HIV infection and those with HIV/TB although the CD4 cell is the basic virus target/CONCLUSION: The study of the proportion of CD8+CD28+ cells among the CD8 lymphocytes is of more informative value than the determination of that of CD4+CD28+ among the CD4 lymphocytes.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
A A Popova
Центральный НИИ эпидемиологии Роспотребнадзора
Email: asya-med@mail.ru
11123 Москва, ул. Новогиреевская, д. 3а
A V Kravchenko
Центральный НИИ эпидемиологии Роспотребнадзора
Email: kravtchenko@hivrussia.net
G M Kozhevnikova
Российский университет дружбы народов, Москва
V N Zimina
Московский городской научно-практический центр борьбы с туберкулезом Департамента здравоохранения Москвы
Email: vera-zim@yandex.ru
References
- Батыров Ф.А., Климов Г.В. Комплексные методы лучевой диагностики туберкулеза у больных ВИЧ-инфекцией в многопрофильной туберкулезной клинической больнице. Матер. VIII Рос. съезда фтизиатров "Туберкулез в России год 2007". М 2007: 356.
- Бурместр Г.-Р., Пецутто А. Наглядная иммунология. Пер. с англ. М: БИНОМ. Лаборатория знаний 2007; 320.
- Janeway C.A., Travers P., Walport M. et al. (еds). Immunobiology. 5th ed. New-York: Garland Publishing 2001.
- Klein J., Horejsi V. Immunology. 2nd ed. Wiley-Blackwell 1997; 736.
- Levy Y., Durier C., Krzysiek R. et al. Effects of interleukin-2 therapy combined with highly active antiretroviral therapy on immune restoration in HIV-1 infection: a randomized controlled trial. AIDS 2003; 17: 343-351.
- Бобкова М.Р. Иммунитет и ВИЧ-инфекция (популярные лекции). М: Олимпия Пресс 2006; 240.
- Swigut T., Shohdy N., Skowronski J. Mechanism for down-regulation of CD28 by Nef. EMBO J 2001; 20: 1593-1604.
- Effros R.B., Allsopp R., Chiu C.P. et al. Shortened telomeres in the expanded CD28-CD8+ cell subset in HIV disease implicate replicative senescence in HIV pathogenesis. AIDS 1996; 10: 17-22.
- Valenzuela H.F., Effros R.B. Divergent telomerase and CD28 expression patterns in human CD4 and CD8 T cells following repeated encounters with the same antigenic stimulus. Clin Immunol 2002; 105: 117-125.
- Choremi-Papadopoulou H., Panagiotou N., Samouilidou E. et al. CD28 costimulation and CD28 expression in T lymphocyte subsets in HIV-1 infection with and without progression to AIDS. Clin Exp Immunol 2000; 119: 499-506.
- Ситдыкова Ю.Р. Влияние антиретровирусной терапии на динамику CD4-лимфоцитов и экспрессию Т-клетками иммунологических маркеров у пациентов, инфицированных ВИЧ: Автореф. дис. ... канд. мед. наук. М 2007; 42.
Supplementary files
