Email this article Clinical features of osteoarthritis in patients with metabolic syndrome
- Authors: Vasilyeva LV1, Lakhin DI2,3
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Affiliations:
- ГБОУ ВПО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России
- ГБОУ ВПО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России, Воронеж, Россия
- ГУЗ «Липецкая областная клиническая больница», Липецк, Россия
- Issue: Vol 89, No 5 (2017)
- Pages: 65-68
- Section: Editorial
- URL: https://journal-vniispk.ru/0040-3660/article/view/32217
- DOI: https://doi.org/10.17116/terarkh201789565-68
- ID: 32217
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Abstract
Aim. To estimate clinical and laboratory parameters in patients with osteoarthritis (OA) and in those with OA and metabolic syndrome (MS). Subjects and methods. 164 patients with OA were examined and divided into 2 groups of 82 people: a study group (patients with MS) and a control one (those without MS). OA was defined according to the diagnostic criteria described by R.D. Althmann (1995). MS was identified based on the criteria developed by the International Diabetes Federation (2005). The location of affected and swollen joints was determined according to the Richie index; the intensity of pain syndrome was measured by a visual analogue scale at rest and on movement; the WOMAC and Lequesne indexes were estimated in the patients. Erythrocyte sedimentation rate and C-reactive protein and tumor necrosis factor-α levels were determined from laboratory data. Results. In the MS group, the frequency of joint injuries at various sites, the prevalence of synovitis, and the intensity of pain and inflammation were significantly higher than in the non-MS group. Conclusion. The negative impact of MS on the clinical picture of OA can be inferred by the findings.
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##article.viewOnOriginalSite##About the authors
L V Vasilyeva
ГБОУ ВПО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава РоссииВоронеж, Россия
D I Lakhin
ГБОУ ВПО «Воронежский государственный медицинский университет им. Н.Н. Бурденко» Минздрава России, Воронеж, Россия; ГУЗ «Липецкая областная клиническая больница», Липецк, Россия
References
- Jacobsson LT, Turesson C, Hanson RL, Pillemer S, Sievers ML, Pettitt DJ, Bennett PH, Knowler WC. Joint swelling as a predictor of death from cardiovascular disease in a population study of Pima. Arthritis & Rheumatism. 2001;44:1170-1176. doi: 10.1002/1529-0131(200105)44:5<1170::aid-anr200>3.0.co;2-t
- Daskalopoulou SS, Mikhailidis DP, Elisaf M. Prevention and treatment of metabolic syndrome. Angiology. 2004;55(6):589-612. doi: 10.1177/00033197040550i601
- Baranova AV. Adipokine genetics: Unbalanced protein secretion by human adipose tissue as a cause of the metabolic syndrome. Russian Journal of Genetics. 2008;44(10):1338-1355. doi: 10.1134/s1022795408100050
- Кратнов А.Е., Лопатникова Е.Н., Кратнов А.А. Внутриклеточный метаболизм нейтрофилов и риск развития сахарного диабета 2 типа у больных с метаболическим синдромом. Сахарный диабет. 2002;15(2):13-16. doi: 10.14341/2072-0351-5512
- Orellana C, Navarro N, Vázquez I, Moreno M, Galisteo C, Gratacós J, Larrosa M. Association Between Metabolic Syndrome And Synovitis In Patients With Knee Osteoarthritis. Osteoarthritis and Cartilage. 2011;19(1):S142. doi: 10.1016/S1063-4584(11)60333-6
- Ford ES. The metabolic syndrome and mortality from cardiovascular disease and all-causes: findings from the National Health and Nutrition Examination Survey II Mortality Study. Atherosclerosis. 2004;173(2):309-314. doi: 10.1016/j.atherosclerosis.2003.12.022
- Wenham CYJ, Grainger AJ, Conaghan PG. The role of imaging modalities in the diagnosis, differential diagnosis and clinical assessment of peripheral joint osteoarthritis. Osteoarthritis and Cartilage. 2014;22(10):1692-1702. doi: 10.1016/j.joca.2014.06.005
- Насонов Е.Л., Александрова Е.Н., Новиков А.А. Аутоиммунные ревматические заболевания — проблемы иммунопатологии и персонифицированной терапии. Вестник Российской академии медицинских наук. 2015;70(2):169-182. doi: 10.15690/vramn.v70i2.1310
- Kadam UT, Jordan K, Croft PR. Clinical comorbidity in patients with osteoarthritis: a case-control study of general practice consulters in England and Wales. Annals of the Rheumatic Diseases. 2004;63(4):408-414. doi: 10.1136/ard.2003.007526
- Reaven GV. Role of insulin resistance in human disease. Diabetes. 1988;37:1595-1607. doi: 10.2337/diab.37.12.1595
- Caporali R, Cimmino MA, Sarzi-Puttini P, Scarpa R, Parazzini F, Zaninelli A, Ciocci A, Montecucco C. Comorbid conditions in the AMICA study patients: effects on the quality of life and drug prescriptions by general practitioners and specialists. Seminars in Arthritis & Rheumatism. 2005;35(1):31-37. doi: 10.1016/j.semarthrit.2005.02.004
- Соловьева И.В., Стребкова Е.А., Алексеева Л.И., Мкртумян А.М. Влияние снижения массы тела на клинические проявления остеоартроза коленных суставов. Ожирение и метаболизм. 2014;11(4):41-47. doi: 10.14341/omet2014441-47
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