Targeting Liposomes Loaded with DNA Mimetics for the Directional Elimination of Tumor Cells
- 作者: Shramova E.I.1, Proshkina G.M.1, Deyev S.M.1,2
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隶属关系:
- Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
- Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
- 期: 卷 40, 编号 1 (2023)
- 页面: 66-70
- 栏目: Articles
- URL: https://journal-vniispk.ru/0233-4755/article/view/135027
- DOI: https://doi.org/10.31857/S0233475523010097
- EDN: https://elibrary.ru/NTWQTL
- ID: 135027
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详细
The article presents an innovative method for the targeted elimination of tumor cells of a certain molecular profile by inactivating the transcription of genes of common subunits of human RNA polymerases using complementary DNA mimetics delivered into cells inside liposomes modified on the outer surface with targeting molecules. It was shown that inactivation of genes of RNA polymerase common subunits Rpb5, Rpb6, or Rpb8 by the proposed method, depending on the chosen target, causes death of up to 50% of HER2-positive human breast cancer cells in culture.
作者简介
E. Shramova
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: shramova.e.i@gmail.com
Russia, 117997, Moscow
G. Proshkina
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences
Email: shramova.e.i@gmail.com
Russia, 117997, Moscow
S. Deyev
Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences; Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)
Email: shramova.e.i@gmail.com
Russia, 117997, Moscow; Russia, 119991, Moscow
参考
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