Polymorphism of the APOE gene: prevalence of phenotypes in the population and an association with the development of Alzheimer's disease
- Authors: Volobuyev A.N.1, Romanchuk P.I.1, Romanchuk N.P.1, Krasnov S.V.1, Davydkin I.L.1
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Affiliations:
- Samara State Medical University
- Issue: Vol 34, No 6 (2023)
- Pages: 73-75
- Section: From Practice
- URL: https://journal-vniispk.ru/0236-3054/article/view/250484
- DOI: https://doi.org/10.29296/25877305-2023-06-15
- ID: 250484
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Abstract
Based on the Hardy–Weinberg theory and statistical studies, the authors analyzedthe prevalence of different APOE gene alleles in the populationto reveal the relatioship between the alelle structure of a phenotype and the risk for Alzheimer's disease. Based on the concept of dominant and recessive zygote structures of allelic polymorphism of the APOE gene, it was shown that there must be three phenotypes that determine the risk for Alzheimer's disease. The prevalence of these phenotypes in the human population was studied.
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##article.viewOnOriginalSite##About the authors
A. N. Volobuyev
Samara State Medical University
Author for correspondence.
Email: volobuev47@yandex.ru
Biol.D., Professor
Russian Federation, SamaraP. I. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences
Russian Federation, SamaraN. P. Romanchuk
Samara State Medical University
Email: volobuev47@yandex.ru
Candidate of Medical Sciences, Associate Professor
Russian Federation, SamaraS. V. Krasnov
Samara State Medical University
Email: volobuev47@yandex.ru
Biol.D, Professor
Russian Federation, SamaraI. L. Davydkin
Samara State Medical University
Email: volobuev47@yandex.ru
Doctor of Medical Sciences, Professor
Russian Federation, SamaraReferences
- Ткачева О.Н., Рунихина Н.К., Котовская Ю.В. Диагностика, Профилактика и лечение старческой астении и других гериатрических синдромов. М.: ФГОБУ ВО РНИМУ им. Н.И. Пирогова Минздрава России, 2017; 126 с. [Tkacheva O.N., Runikhina N.K., Kotovskaya Yu.V. Diagnostika, Profilaktika i lechenie starcheskoi astenii i drugikh geriatricheskikh sindromov. M.: FGOBU VO RNIMU im. N.I. Pirogova Minzdrava Rossii, 2017; 126 р. (in Russ.)].
- Фогель Ф., Мотульски А. Генетика человека. Т.1. Пер. с англ. М.: Мир, 1989. 310 с. [Vogel F., Motulsky A.G. Human Genetics. V.1. Transl. from engl. M.: Mir, 1989; 310 р. (in Russ)].
- Железнякова А.В. Генетические факторы развития хронической болезни почек у больных сахарным диабетом 2 типа. Дисс. … канд. мед. наук. М.: ФГБУ «Эндокринологический научный центр» МЗ РФ, 2015; 125 с. [Zheleznyakova A.V. Geneticheskie faktory razvitiya khronicheskoi bolezni pochek u bol'nykh sakharnym diabetom 2 tipa. Diss. … kand. med. nauk. M.: FGBU «Endokrinologicheskii nauchnyi tsentr» MZ RF, 2015; 125 р. (in Russ.)].
- Козлов Н.Н. Математический анализ генетического кода. М.: БИНОМ. Лаборатория знаний, 2015; 215 с. [Kozlov N.N. Matematicheskii analiz geneticheskogo koda. M.: BINOM. Laboratoriya znanii, 2015; 215 р. (in Russ.)].
- Lahoz C., Schaefer E.J., Cupples L.A. et al. Apolipoprotein E genotype and cardiovascular disease in the Framingham Heart Study. Atherosclerosis. 2001; 154: 529–37. doi: 10.1016/s0021-9150(00)00570-0
- Волобуев А.Н. Основы медицинской и биологической физики. Самара: ООО «Самарский дом печати», 2011; 672 с. [Volobuev A.N. Osnovy meditsinskoi i biologicheskoi fiziki. Samara: OOO «Samarskii dom pechati», 2011; 672 р. (in Russ.)].
- Farrer L.A., Cupples L.A., Haines J.L. et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA. 1997; 278 (16): 1349–56.
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