Modern aspects of the use of hawthorn in clinical practice

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Resumo

The article analyzes scientific research on the phytochemical and pharmacological activity of hawthorn. It has been shown that hawthorn has cardiotonic, vasodilating, antiarrhythmic, and antioxidant effects, which makes it possible to use it in the complex therapy of chronic heart failure, arterial hypertension and coronary heart disease, neurogenic and cardiac disorders. The advantages and limitations of using hawthorn preparations in various diseases and pathological conditions are described in detail. Special attention is paid to one of the urgent pharmacological and therapeutic problems – the safety of hawthorn use. The emphasis is placed on the need for further research and its most important areas.

Sobre autores

T. Potupchik

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Autor responsável pela correspondência
Email: potupchik_tatyana@mail.ru
ORCID ID: 0000-0003-1133-4447
Código SPIN: 8353-3513

Candidate of Medical Sciences

Rússia, Krasnoyarsk

L. Evert

Krasnoyarsk Scientific Center of the Siberian Branch of the Russian Academy of Sciences; N.F. Katanov Khakass State University, Ministry of Education and Science of Russia

Email: potupchik_tatyana@mail.ru
ORCID ID: 0000-0003-0665-7428
Código SPIN: 4099-8973

MD, Scientific Research Institute of Medical Problems of the North; Medical Institute

Rússia, Krasnoyarsk; Abakan

O. Averyanova

Medical and diagnostic clinic «Computer Technology Medicine»

Email: potupchik_tatyana@mail.ru
ORCID ID: 0009-0001-5523-2867
Rússia, Krasnoyarsk

V. Zhidkov

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Ministry of Health of Russia

Email: potupchik_tatyana@mail.ru
ORCID ID: 0009-0001-1346-5371
Código SPIN: 8246-2033
Rússia, Krasnoyarsk

Bibliografia

  1. Dahmer S., Scott E. Health effects of hawthorn. Am Fam Physician. 2010; 81 (4): 465–8.
  2. Wu M., Liu L., Xing Y. et al. Roles and mechanisms of hawthorn and its extracts on atherosclerosis: a review. Front Pharmacol. 2020; 11: 118. doi: 10.3389/fphar.2020.00118
  3. Nazhand A., Lucarini M., Durazzo A. et al. Hawthorn (Crataegus spp.): an updated overview on its beneficial properties. Forests. 2020; 11 (5): 564. doi: 10.3390/f11050564
  4. Джатдоева Д.Т. Комплексная оценка применения лекарственных растений в современной медицине в зависимости от биоорганических процессов. Вестник Курской государственной сельскохозяйственной академии. 2022; 9: 113–9 [Dzhatdoeva D.T. Comprehensive assessment of the use of medicinal plants in modern medicine depending on bioorganic processes. Bulletin of the Kursk State Agricultural Academy. 2022; 9: 113–9 (in Russ.)].
  5. Самылина И.А., Сорокина А.А., Пятигорская Н.В. Боярышник (Crataegus): возможности медицинского применения. Фарматека. 2010; 8: 83–5 [Samylina I.A., Sorokina A.A., Pyatigorskaya N.V. Hawthorn (Crataegus): possibilities of medical application. Pharmaceutical library. 2010; 8: 83–5 (in Russ.)].
  6. Orhan I.E. Phytochemical and Pharmacological Activity Profile of Crataegus oxyacantha L. (Hawthorn) – A Cardiotonic Herb. Curr Med Chem. 2018; 25 (37): 4854–65. doi: 10.2174/0929867323666160919095519
  7. Zorniak M. Szydło B. Krzemiński T.F. Crataegus special extract WS® 1442: up-to-date review of experimental and clinical experiences. J Physiol Pharmacol. 2017; 68 (4): 521–6.
  8. Государственный реестр лекарственных средств [The State Register of Medicines (in Russ.)]. URL: https://grls.rosminzdrav.ru/
  9. Кардиотон [Электронный ресурс] [Cardioton. [Electronic resource] (in Russ.)]. URL: https://rlsnet.ru
  10. Holubarsch C.J., Colucci W.S., Meinertz T. et al. The efficacy and safety of Crataegus extract WS 1442 in patients with heart failure: the SPICE trial. Eur J Heart Fail. 2008; 10 (12):1 255–63. doi: 10.1016/j.ejheart.2008.10.004
  11. Zick S.M., Vautaw B.M., Gillespie B. et al. Hawthorn Extract Randomized Blinded Chronic Heart Failure (HERB CHF) trial. Eur J Heart Fail. 2009; 11 (10): 990–9. doi: 10.1093/eurjhf/hfp116
  12. Cloud A., Vilcins D., McEwen B. The effect of hawthorn (Crataegus spp.) on blood pressure: A systematic review. Advances in Integrative Medicine. 2020; 7 (3): 167–75. doi: 10.1016/j.aimed.2019.09.002
  13. Walker A.F., Marakis G., Morris A.P. et al. Promising hypotensive effect of hawthorn extract: A randomized double-blind pilot study of mild, essential hypertension. Phytother Res. 2002; 16 (1): 48–54. doi: 10.1002/ptr.947
  14. Abbasi M., Gohari S., Ahangar H. et al. Efficacy of Hawthorn fruit extract on blood pressure and quality of sleep in patients with hypertension along with sleep disorders: A randomized double-blind controlled trial. J Cont Med Sci. 2021; 7 (4): 196–201. doi: 10.22317/jcms.v7i4.1017
  15. Дедов Д.В. Применение боярышника кроваво-красного и плодов шиповника в составе препарата Кардиотон в профилактике различных заболеваний. Врач. 2022; 33 (12): 88–91 [Dedov D.V. Application of hawthorn blood-red and rosehip fruits in the drug Kardioton in the prevention of various diseases. Vrach. 2022; 33 (12): 88–91 (in Russ.)]. doi: 10.29296/25877305-2022-12-17
  16. Дедов Д.В. Препарат Кардиотон: состав, фармакологические свойства, возможности профилактики сердечно-сосудистых заболеваний. Врач. 2022; 33 (9): 36–8 [Dedov D.V. The drug Cardioton: composition, pharmacological properties, the possibilities of preventing cardiovascular diseases. Vrach. 2022; 33 (9): 36–8 (in Russ.)]. doi: 10.29296/25877305-2022-09-06
  17. Дедов Д.В. Препарат «Кардиотон»: фармакологические свойства боярышника кроваво-красного, возможность применения у пациентов с сердечно-сосудистыми заболеваниями. Врач. 2023; 34 (5): 78–82 [Dedov D.V. Cardiotone: pharmacological properties of hawthorn blood-red, possibility of use in patients with cardiovascular diseases. Vrach. 2023; 34 (5): 78–82. (in Russ.)]. doi: 10.29296/25877305-2023-05-14
  18. Хабибулина М.М., Шамилов М.Д., Коннова С.С. и др. Современные подходы к лечению дизритмий. Врач. 2025; 36 (5): 83–6 [Khabibulina M.M., Shamilov M.D., Konnova S.S. et al. Modern approaches to the treatment of dysrhythmias. Vrach. 2025; 36 (5): 83–6 (in Russ.)]. doi: 10.29296/25877305-2025-05-17
  19. Хабибулина М.М., Елистратов Д.Г., Шамилов М.Д. Антиишемическая и кардиометаболическая терапия при сердечно-сосудистой патологии. Врач. 2024; 35 (4): 47–50 [Khabibulina M.M., Elistratov D.G., Shamilov M.D. Anti-ischemic and cardiometabolic therapy in cardiovascular pathology. Vrach. 2024; 35 (4): 47–50 (in Russ.)]. doi: 10.29296/25877305-2024-04-09
  20. Хабибулина М.М., Елистратов Д.Г., Шамилов М.Д. Антигипертензивная и кардиометаболическая терапия при артериальной гипертензии. Врач. 2025; 36 (4): 49–54 [Khabibulina M.M., Elistratov D.G., Shamilov M.D. Antihypertensive and cardiometabolic therapy in arterial hypertension. Vrach. 2025; 36 (4): 49–54 (in Russ.)]. doi: 10.29296/25877305-2025-04-10

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