Clinical manifestations of gastroesophageal reflux disease and anxiety in patients with metabolic syndrome
- Autores: Shrayner E.V.1,2, Kalashnikova K.E.1, Bystrova V.I.1,2, Lukichev D.A.1, Smirnova I.I.3, Sultanova A.N.3, Kudlay D.A.1,4,5
- 
							Afiliações: 
							- Novosibirsk State University
- Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences
- Novosibirsk State Medical University, Ministry of Health of Russia
- I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
- M.V. Lomonosov Moscow State University
 
- Edição: Volume 36, Nº 8 (2025)
- Páginas: 71-74
- Seção: From Practice
- URL: https://journal-vniispk.ru/0236-3054/article/view/310725
- DOI: https://doi.org/10.29296/25877305-2025-08-14
- ID: 310725
Citar
Resumo
Metabolic syndrome (MS) is a global medical and social concern that significantly impacts various physiological systems, including the gastrointestinal tract. One of the most common associated pathologies is gastroesophageal reflux disease (GERD). This study aimed to evaluate the severity of clinical manifestations of GERD and anxiety disorders in patients with MS. A comparative analysis was conducted between two groups: patients with combined MS and GERD, and patients with isolated GERD. The study included clinical examination, assessment using the Spielberger State-Trait Anxiety Inventory (STAI), and instrumental diagnostics. The results demonstrated higher levels of anxiety and more severe GERD symptoms in patients with MS. A statistically significant association was revealed between MS and esophageal mucosal injury.
Palavras-chave
Texto integral
##article.viewOnOriginalSite##Sobre autores
E. Shrayner
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences
							Autor responsável pela correspondência
							Email: sch704@icloud.com
				                	ORCID ID: 0000-0003-3606-4068
				                	Código SPIN: 1089-6080
																		                								
Candidate of Medical Sciences
Rússia, Novosibirsk; NovosibirskK. Kalashnikova
Novosibirsk State University
														Email: sch704@icloud.com
				                	ORCID ID: 0009-0003-2324-7102
				                																			                												                	Rússia, 							Novosibirsk						
V, Bystrova
Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences
														Email: sch704@icloud.com
				                	ORCID ID: 0000-0003-3522-5384
				                	Código SPIN: 4479-6770
																		                												                	Rússia, 							Novosibirsk; Novosibirsk						
D. Lukichev
Novosibirsk State University
														Email: sch704@icloud.com
				                	ORCID ID: 0009-0000-5888-0651
				                																			                												                	Rússia, 							Novosibirsk						
I. Smirnova
Novosibirsk State Medical University, Ministry of Health of Russia
														Email: sch704@icloud.com
				                	ORCID ID: 0009-0009-1458-1399
				                	Código SPIN: 8992-2884
																		                												                	Rússia, 							Novosibirsk						
A. Sultanova
Novosibirsk State Medical University, Ministry of Health of Russia
														Email: sch704@icloud.com
				                	ORCID ID: 0000-0001-6420-6591
				                	Código SPIN: 5719-0860
																		                								
MD
Rússia, NovosibirskD. Kudlay
Novosibirsk State University; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); M.V. Lomonosov Moscow State University
														Email: sch704@icloud.com
				                	ORCID ID: 0000-0003-1878-4467
				                	Código SPIN: 4129-7880
																		                								
Professor, Corresponding Member of the Russian Academy of Sciences, MD
Rússia, Novosibirsk; Moscow; MoscowBibliografia
- Vrdoljak J., Kumric M., Vilovic M. et al. Can Fasting Curb the Metabolic Syndrome Epidemic? Nutrients. 2022; 14: 456. doi: 10.3390/nu14030456
- Hsieh Y.H., Wu M.F., Yang P.Y. et al. What is the impact of metabolic syndrome and its components on reflux esophagitis? A cross-sectional study. BMC Gastroenterol. 2019; 19: 33. doi: 10.1186/s12876-019-0950-z
- Городецкая И.В., Коневалова Н.Ю., Захаревич В.Г. Исследование ситуативной и личностной тревожности студентов. Вестник Витебского государственного медицинского университета. 2019; 18 (5): 120–7 [Gorodetskaya I.V., Konevalova N.Y., Zakharevich V.G. The study of the situational and personal anxiety of students. Vestnik VGMU. 2019; 18 (5): 120–7 (in Russ.)]. doi: 10.22263/2312-4156.2019.5.120
- Zamani M., Alizadeh-Tabari S., Chan W.W. et al. Association Between Anxiety/Depression and Gastroesophageal Reflux: A Systematic Review and Meta-Analysis. Am J Gastroenterol. 2023; 118 (12): 2133–43. doi: 10.14309/ajg.0000000000002411
- Choi J.M., Yang J.I., Kang S.J. et al. Association Between Anxiety and Depression and Gastroesophageal Reflux Disease: Results From a Large Cross-sectional Study. J Neurogastroenterol Motil. 2018; 24 (4): 593–602. doi: 10.5056/jnm18069
- Ji S., Chen Y., Zhou Y. et al. Association between anxiety and metabolic syndrome: An updated systematic review and meta-analysis. Front Psychiatry. 2023; 14: 1118836. doi: 10.3389/fpsyt.2023.1118836
- El-Serag H.B., Sweet S., Winchester C.C. et al. Update on the epidemiology of gastro-oesophageal reflux disease: a systematic review. Gut. 2014; 63 (6): 871–80. doi: 10.1136/gutjnl-2012-304269
- Ghoshal U.C., Sonthalia N., Roy A. et al. Metabolic Syndrome and Gastroesophageal Reflux Disease: Clinical Remission with Treatment, Beyond an Epidemiological Association. J Neurogastroenterol Motil. 2025; 31 (1): 1–2. doi: 10.5056/jnm24175
- Gyawali C.P., Yadlapati R., Fass R. et al. Updates to the modern diagnosis of GERD: Lyon consensus 2.0. Gut. 2024; 73 (2): 361–71. doi: 10.1136/gutjnl-2023-330616
- Calabrese F., Pasta A., Bodini G. et al. Applying Lyon consensus criteria in the work-up of patients with extra-oesophageal symptoms – A multicentre retrospective study. Aliment Pharmacol Ther. 2024; 59 (9): 1134–43. doi: 10.1111/apt.17934
- Karimian M., Salamati M., Azami M. The relationship between metabolic syndrome and increased risk of Barrett's esophagus: an updated systematic review and meta-analysis. BMC Gastroenterol. 2020; 20 (1): 138. doi: 10.1186/s12876-020-01267-2
- Kim Y., Park J.H., Kim D.H. et al. Impact of Metabolic Health and Its Changes on Erosive Esophagitis Remission: A Cohort Study. J Neurogastroenterol Motil. 2025; 31 (1): 43–52. doi: 10.5056/jnm24058
Arquivos suplementares
 
				
			 
						 
						 
						 
						 
					 
				
 Acesso aberto
		                                Acesso aberto Acesso está concedido
						Acesso está concedido Somente assinantes
		                                		                                        Somente assinantes
		                                					


