Clinical manifestations of gastroesophageal reflux disease and anxiety in patients with metabolic syndrome

E. V. Shrayner; Шрайнер Е. В.; K. E. Kalashnikova; Калашникова К. Е.; V, I. Bystrova; Быстрова В. И.; D. A. Lukichev; Лукичев Д. А.; I. I. Smirnova; Смирнова И. И.; A. N. Sultanova; Султанова А. Н.; D. A. Kudlay; Кудлай Д. А.

doi:10.29296/25877305-2025-08-14

Clinical manifestations of gastroesophageal reflux disease and anxiety in patients with metabolic syndrome

Authors: Shrayner E.V.¹^,2, Kalashnikova K.E.¹, Bystrova V.I.¹^,2, Lukichev D.A.¹, Smirnova I.I.³, Sultanova A.N.³, Kudlay D.A.¹^,4^,5
Affiliations:
1. Novosibirsk State University
2. Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences
3. Novosibirsk State Medical University, Ministry of Health of Russia
4. I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)
5. M.V. Lomonosov Moscow State University
Issue: Vol 36, No 8 (2025)
Pages: 71-74
Section: From Practice
URL: https://journal-vniispk.ru/0236-3054/article/view/310725
DOI: https://doi.org/10.29296/25877305-2025-08-14
ID: 310725

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Abstract

Metabolic syndrome (MS) is a global medical and social concern that significantly impacts various physiological systems, including the gastrointestinal tract. One of the most common associated pathologies is gastroesophageal reflux disease (GERD). This study aimed to evaluate the severity of clinical manifestations of GERD and anxiety disorders in patients with MS. A comparative analysis was conducted between two groups: patients with combined MS and GERD, and patients with isolated GERD. The study included clinical examination, assessment using the Spielberger State-Trait Anxiety Inventory (STAI), and instrumental diagnostics. The results demonstrated higher levels of anxiety and more severe GERD symptoms in patients with MS. A statistically significant association was revealed between MS and esophageal mucosal injury.

Keywords

metabolic syndrome, gastroesophageal reflux disease, anxiety, obesity, esophagitis

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About the authors

E. V. Shrayner

Novosibirsk State University; Institute of Chemical Biology and Fundamental Medicine of Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: sch704@icloud.com
ORCID iD: 0000-0003-3606-4068
SPIN-code: 1089-6080

Candidate of Medical Sciences

Russian Federation, Novosibirsk; Novosibirsk

Russian Federation, Novosibirsk

D. A. Kudlay

Novosibirsk State University; I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University); M.V. Lomonosov Moscow State University

Email: sch704@icloud.com
ORCID iD: 0000-0003-1878-4467
SPIN-code: 4129-7880

Professor, Corresponding Member of the Russian Academy of Sciences, MD

Russian Federation, Novosibirsk; Moscow; Moscow

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