Combined ionizing radiation exposure improves behavioral symptoms and modulates brain innate immune system activity in the Tau P301S mice line

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Abstract

Tauopathies are a group of neurodegenerative diseases associated with abnormal phosphorylation and aggregation of the microtubule-associated tau-protein. Currently, there is no pathogenetic treatment for tauopathies, but the process of neuroinflammation that accompanies the diseases appears to be a promising therapeutic target. According to the literature, ionizing radiation (IR) may be one of the effective tools to manage neuroinflammation. Here, we investigated the effects of combined ionizing radiation (γ-quanta and carbon-12 nuclei) on locomotor abilities and markers of microglia activation in the brain of transgenic Tau P301S mice line reproducing tauopathy. Irradiation led to improvement in behavioral symptoms of the mice: increased endurance (in the early symptomatic stage) and enhanced locomotor activity (in the terminal stage). At the same time, irradiation resulted in increased levels of pro-inflammatory and anti-inflammatory cytokines and chemokines in the cerebellum and, to a lesser extent, in the hippocampus of irradiated mice. The obtained data indicate a significant modulating effect of IR on the innate immune system, and also indicate a high potential of radiotherapy as a therapeutic method for the treatment of neurodegeneration.

About the authors

V. S. Kokhan

“Serbsky National Medical Research Center of Psychiatry and Narcology” Russian Ministry of Health

Email: shamakina.i@serbsky.ru
Russian Federation, 119002 Moscow

R. A. Ageldinov

Scientific Center for Biomedical Technologies of the Federal Medical and Biological Agency of Russia

Email: shamakina.i@serbsky.ru
Russian Federation, 143442 Moscow Region

P. K. Anokhin

“Serbsky National Medical Research Center of Psychiatry and Narcology” Russian Ministry of Health; Artificial Intelligence Research Institute

Email: shamakina.i@serbsky.ru
Russian Federation, 119002 Moscow; 121170 Moscow

I. Y. Shamakina

“Serbsky National Medical Research Center of Psychiatry and Narcology” Russian Ministry of Health

Author for correspondence.
Email: shamakina.i@serbsky.ru
Russian Federation, 119002 Moscow

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