Evaluation of plant extract stress-protective activity
- Authors: Ferubko E.V.1, Dargaeva T.D.1, Rendyuk T.D.2
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Affiliations:
- All-Russian Research Institute of Medicinal and Aromatic Plants
- Sechenov First Moscow State Medical University, (Sechenov University)
- Issue: Vol 72, No 4 (2023)
- Pages: 23-29
- Section: Pharmaceutical chemistry and pharmacognosy
- URL: https://journal-vniispk.ru/0367-3014/article/view/142781
- DOI: https://doi.org/10.29296/25419218-2023-04-03
- ID: 142781
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Abstract
Introduction. One of the most important tasks of medical science at the present stage is the development and introduction of new effective medicines intended for the prevention and treatment of socially significant diseases of the digestive organs, including stomach ulcer. Given the polyvalence of the etiology of gastric ulcer, a possible approach to pharmacotherapy of this disease may be the use of multicomponent plant compositions.
Objective: study of stress-protective activity of a multicomponent extract under immobilized stress model conditions in laboratory animals.
Material and methods. Acute toxicity of the developed plant extract was studied according to the Kerber method. Stress-protective activity was studied with 7-day administration of the extract at an experimental therapeutic dose of 150 mg/kg against the background of an experimental model of immobilized stress in rats. For this purpose, stress reaction parameters were determined: spleen and thymus involution, number of lesions in gastric mucosa with Pauls index count. Activity of antioxidant system and intensity of free radical oxidation processes by catalase activity and content of malonic dialdehyde were determined in blood serum.
Results. The obtained data indicate the presence of a reliably pronounced stress-protective effect in the studied extract during its course administration to rats due to the obstacle to the development of signs of the Selje triad. Also, the extract has a reliably pronounced antioxidant and membrane-stabilizing effect.
Conclusion. Multicomponent plant extract when administered in course in experimental therapeutic dose against background of immobilized stress in rats shows pronounced stress-protective effect, has antioxidant and membrane-stabilizing effect. The developed extract is a promising object for creating a new effective drug for use in complex therapy in patients with gastric ulcer.
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##article.viewOnOriginalSite##About the authors
Ekaterina Vladimirovna Ferubko
All-Russian Research Institute of Medicinal and Aromatic Plants
Author for correspondence.
Email: ferubko@vilarnii.ru
ORCID iD: 0000-0003-1949-2597
Doctor of Medical Sciences, Head of Department of Experimental Pharmacology
Russian Federation, MoscowTamara Darizhapovna Dargaeva
All-Russian Research Institute of Medicinal and Aromatic Plants
Email: vilarnii@mail.ru
ORCID iD: 0000-0002-0722-9479
Doctor of Pharmaceutical Sciences, Professor, Chief Researcher at the Department of Chemistry of Natural Compounds
Russian Federation, MoscowTamara Danilovna Rendyuk
Sechenov First Moscow State Medical University, (Sechenov University)
Email: rendyuk_t_d@staff.sechenov.ru
ORCID iD: 0000-0002-0359-3847
PhD of Pharmaceutical Sciences, Associate Professor, Department of Pharmaceutical natural Sciences, Institute of Pharmacy
Russian Federation, Trubetskaya str., 8/2, Mosсow, 119991References
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