Substantiation of the composition and technology of production of medicinal lollipops with CO2-extracts of ginger rhizomes and dandelion roots
- Authors: Stepanova E.F.1, Kulgav E.A.1, Kovtun E.V.1, Pogrebniak L.V.1, Pogrebniak A.V.1, Bokov D.O.2,3
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Affiliations:
- Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
- Sechenov First Moscow State Medical University
- Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
- Issue: Vol 74, No 6 (2025)
- Pages: 42-49
- Section: Technology of medicines
- URL: https://journal-vniispk.ru/0367-3014/article/view/316991
- DOI: https://doi.org/10.29296/25419218-2025-06-05
- ID: 316991
Cite item
Abstract
Introduction. It is known that the combination of therapeutic physical activity and a properly selected diet gives positive results if the patient's goal is to return his weight to normal in terms of age, height and general constitution. However, dietary adjustments are not always sufficient to achieve weight loss. The patterns of individual metabolism that have become entrenched over many years of malnutrition continue to irrationally distribute metabolic products even with diet correction. This undesirable phenomenon can be corrected by introducing supplements into the diet that accelerate metabolism and promote the elimination of undesirable metabolites.
Objective. Development of the composition and technology of medicinal lollipops with CO2 extracts of ginger rhizomes and dandelion roots, which will be offered for use in gastroenterology to accelerate metabolism (weight loss products). To achieve this goal, the following tasks were solved: the need to create medicinal lollipops was justified; the selection of active and auxiliary substances for the production of lollipops was carried out; the optimal technological scheme of production was selected; test samples of lollipops were made; their quality was assessed.
Material and methods. The studies were conducted according to the methods of the State Pharmacopoeia (SP) XIV and XV editions. In the experimental studies, biologically active substances and auxiliary substances obtained from manufacturers with the corresponding analysis protocols according to the requirements of ND were used. CO2-extract of ginger rhizomes and dandelion roots produced at the enterprise Biotsevtika LLC in Dedovsk, Moscow Region were used as the main biologically active substance. Organoleptic properties were assessed subjectively, by checking the appearance, smell, presence of foreign impurities, homogeneity. Both raw materials and finished products were subjected to these tests in accordance with the regulatory documentation.
Results. The composition and technology of medicinal lollipops with CO2-extract of ginger rhizomes and dandelion roots have been developed, the feasibility of which has been confirmed by expert assessments (organoleptic properties), and the technological properties have also been studied. A technological scheme for the production of medicinal lollipops with CO2-extract of ginger rhizomes and dandelion roots has been developed.
Conclusion. Lozenges, as a dosage form, have enough advantages over other dosage forms for internal use, due to which it is optimally suited for the creation of a dosage form for use in gastroenterology, in which it is easy to include the CO2-extract we offer as active substances. The technological studies conducted allowed us to develop the composition and technology of medicinal lozenges with CO2-extract of ginger and dandelion roots. Technological tests of the proposed lozenges were carried out, as a result of which positive consumer properties of this dosage form were revealed.
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##article.viewOnOriginalSite##About the authors
Eleonora Fedorovna Stepanova
Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
Author for correspondence.
Email: e.f.stepanova@mail.ru
ORCID iD: 0000-0002-4082-3330
doctor of Pharmaceutical Sciences, professor, professor of the department of pharmaceutical technology with a course in medical biotechnology Pyatigorsk Medical and Pharmaceutical Institute
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Elena Aleksandrovna Kulgav
Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
Email: elena.kulgav.72@mail.ru
ORCID iD: 0000-0002-9010-3497
SPIN-code: 2829-7010
Сandidate of Pharmaceutical Sciences, Аssociate Professor of the Department of Pharmaceutical Technology with a course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Elena Vladimirovna Kovtun
Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
Email: elena.f.73@mail.ru
ORCID iD: 0000-0003-3437-760X
SPIN-code: 9921-2190
Сandidate of Pharmaceutical Sciences, Аssociate Professor of the Department of Pharmaceutical Technology with a course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Ludmila Vladimirovna Pogrebniak
Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
Email: lyupin@yandex.ru
ORCID iD: 0000-0002-7846-0862
SPIN-code: 2786-3445
Сandidate of Pharmaceutical Sciences, Аssociate Professor of the Department of Pharmaceutical Technology with a course in Medical Biotechnology, Pyatigorsk Medical and Pharmaceutical Institute
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Andrey Vladimirovich Pogrebniak
Federal State Budgetary Educational Institution of Higher Education “VolGMU” of the Ministry of Health of the Russian Federation
Email: Pspa2010@yandex.ru
ORCID iD: 0000-0001-9932-4205
SPIN-code: 8017-4255
Doctor of Chemical Sciences, Professor of the Department of Inorganic, Physical and Colloidal Chemistry, Pyatigorsk Medical and Pharmaceutical Institute
Russian Federation, Kalinin Avenue, 11, Pyatigorsk, 357532Dmitry Olegovich Bokov
Sechenov First Moscow State Medical University; Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
Email: bokov_d_o@staff.sechenov.ru
ORCID iD: 0000-0003-2968-2466
SPIN-code: 7523-5909
Сandidate of Pharmaceutical Sciences, Associate professor, associate professor of the Pharmaceutical Natural Sciences Department at Institute of Pharmacy named after A.P. Nelyubin, Sechenov First Moscow State Medical University (Sechenov University); Researcher, laboratory of chemistry of food products at the Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
Russian Federation, st. Trubetskaya, 8, build. 2, Moscow, 119991;References
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