INVESTIGATION OF NEUTROPHIL MIGRATION VIA LYMPHATIC VESSELS IN THE COURSE OF A. FUMIGATUS-INDUCED INFLAMMATION

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Abstract

Neutrophils are the main eff ector cells that are mediated immune response to exogenous pathogens including opportunistic fungi Aspergillus fumigatus. Neutrophils infi ltrate infl amed tissues and massively die during the fi ght against pathogen. However, in some cases neutrophils survive and migrate to lymphatic vessels to neutralize residual pathogens and activate adaptive immune response. In the present study we characterized the ability of neutrophils to migrate via lymphatic vessels during A. fumigatus conidia-induced infl ammation. As a result, new data about neutrophils migration kinetics to lymphatic vessels and the role of neutrophils in control of fungal spore dissemination in the host organism were obtained.

About the authors

E. L. Bolkhovitina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Author for correspondence.
Email: alenkash83@gmail.com

JRF Laboratory of Cell Interactions,

Moscow

Russian Federation

A. S. Fedorina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Student, Moscow;

Dolgoprugniy

Russian Federation

A. O. Bogorodskiy

Lomonosov Moscow State University

PhD student,

Moscow

Russian Federation

A. O. Smirnova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Lomonosov Moscow State University

Student,

Moscow

Russian Federation

E. N. Chursanova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS;
Moscow Institute of Physics and Technology

Student, Moscow;

Dolgoprugniy

Russian Federation

A. M. Sapozhnikov

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Professor, Head of the Laboratory of Cell Interactions, 

Moscow

Russian Federation

V. I. Borshchevskiy

Lomonosov Moscow State University

PhD, SRF, Laboratory for Advanced Studies of Membrane Proteins,

Moscow

Russian Federation

M. A. Shevchenko

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

PhD, RF, Laboratory of Cell Interactions,

Moscow

Russian Federation

References

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  2. Lu T., Kobayashi S. D., Quinn M. T., Deleo F. R. A NET Outcome. Front Immunol. 2012 Dec 5;3:365.
  3. Abadie V., Badell E., Douillard P., Ensergueix D., Leenen P. J., Tanguy M., Fiette L., Saeland S., Gicquel B., Winter N. Neutrophils rapidly migrate via lymphatics after Mycobacterium bovis BCG intradermal vaccination and shuttle live bacilli to the draining lymph nodes. Blood. 2005 Sep 1;106(5):1843–50.
  4. Shevchenko M.A., Bogorodskiy A.O., Troyanova N.I., Servuli E. A., Bolkhovitina E. L., Büldt G., Fahlke C., Gordeliy V. I., Gensch T., Borshchevskiy V. I., Sapozhnikov A. M. Aspergillus fumigatus Infection-Induced Neutrophil Recruitment and Location in the Conducting Airway of Immunocompetent, Neutropenic, and Immunosuppressed Mice. J Immunol Res. 2018 Jan 18; 2018:5379085.

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Copyright (c) 2019 Bolkhovitina E.L., Fedorina A.S., Bogorodskiy A.O., Smirnova A.O., Chursanova E.N., Sapozhnikov A.M., Borshchevskiy V.I., Shevchenko M.A.

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