β-ENDORPHIN REGULATION OF SECRETORY ACTIVITY OF PERITONEAL CAVITY CELLS IN MICE UNDER STRESS CONDITION
- Authors: Gein S.V.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- Perm State Research University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 742-744
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119472
- DOI: https://doi.org/10.31857/S102872210006717-3
- ID: 119472
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Abstract
It was found that the 2-h immobilization stress reduced the secretion of reactive oxygen species (ROS) and IL-1β by cells of the peritoneal cavity of mice. The introduction to mice of β-endorphin at doses of 100 and 0.0005 μg / kg before immobilization modulated the eff ects of stress.
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About the authors
S. V. Gein
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences;Perm State Research University
Author for correspondence.
Email: gein@iegm.ru
doctor of medicine, deputy director for research Institute of Ecology and Genetics of Microorganisms;
professor, Department of microbiology and immunology,
Perm
Russian FederationReferences
- Bodnar R. Endogenous opiates and behavior: 2014 // Peptides. 2016. 75. 18–70.
- Гейн С. В., Баева Т. А. Биохимия. 2011. 76(3). 379– 390.
- Гейн С. В., Баева Т. А., Небогатиков В. О. // Доклады Академии наук. 2016. 469(6).749–752.
- O`Connor T. M., O`Halloran D. J., Shanahan F. The stress response and the hypotalamic- pituitary- adrenal axis: from molecule to melancholia. Oxford J. Medicine. 2000. 93. 323–333.
- Bilkei-Gorzo A., Racz I., Michel K., Mauer D., Zimmer A., Klingmüller D., Zimmer A. Control of hormonal stress reactivity by the endogenous opioid system. Psychoneuroendocrinology. 2008. 33. 425–436.
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