THE VARIANTS OF DEATH INNATE IMMUNITY CELLS IN CHRONIC OBSTRUCTIVE LUNG DISEASE OBSTRUCTIVE LUNG
- Authors: Zinoviev S.V.1, Plekhova N.G.1, Kondrashova N.M.1
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Affiliations:
- Pacific State Medical University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 772-774
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119543
- DOI: https://doi.org/10.31857/S102872210006703-8
- ID: 119543
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Abstract
A morphological and cytochemical study of the oxidative metabolism of cells bronchoalveolar lavage (BAL) patients with varying degrees of severity chronic obstructive pulmonary disease (COPD) was studed. It was established that along with cell necrosis, enucleation of granulocytes and macrophages is determined, which refers to the morphological feature of programmed death by the formation of extracellular traps – NET-osis. Proven correlation between indicators of netosis, changes in the oxidative metabolism of cells and the degrees of severity of COPD.
About the authors
S. V. Zinoviev
Pacific State Medical University
Author for correspondence.
Email: Sinowev@mail.ru
PhD, Senior Researcher, of the Central Research Laboratory,
Vladivostok
Russian FederationN. G. Plekhova
Pacific State Medical University
Dr, Head of the Central Research Laboratory,
Vladivostok
Russian FederationN. M. Kondrashova
Pacific State Medical University
PhD, assistant professor at the Institute of Therapy and Instrumental Diagnostics,
Vladivostok
Russian FederationReferences
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