THE MODEL OF PSORIASIFORM DERMATITIS IN MICE INDUCED BY INTRADERMAL ADMINISTRATION OF RECOMBINANT HUMAN IL-36γ
- Authors: Kolobov A.A.1, Sazonova T.A.1, Alexandrov G.V.1, Petrov A.V.1
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Affiliations:
- State Research Institute of Highly Pure Biopreparations
- Issue: Vol 22, No 2-2 (2019)
- Pages: 807-809
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119633
- DOI: https://doi.org/10.31857/S102872210006690-4
- ID: 119633
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Abstract
We developed and characterized the model of psoriasiform dermatitis in mice induced by induced by intradermal administration of recombinant human IL-36γ. Induced skin lesions resemble human psoriasis in means of both macroscopic (PASI) and microscopic features (acanthosis, parakeratosis, dermal leucocyte infiltration). This model can be used for anti-psoriatic drugs efficiency research.
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About the authors
A. A. Kolobov
State Research Institute of Highly Pure Biopreparations
Author for correspondence.
Email: al.a.kolobov@hpb.spb.ru
PhD, Junior Scientist of Laboratory of Immunopharmacology,
Saint-Petersburg
Russian FederationT. A. Sazonova
State Research Institute of Highly Pure Biopreparations
Junior Biologist of Department of Preclinical Studies,
Saint-Petersburg
Russian FederationG. V. Alexandrov
State Research Institute of Highly Pure Biopreparations
PhD, Deputy Head of Department of Preclinical Studies,
Saint-Petersburg
Russian FederationA. V. Petrov
State Research Institute of Highly Pure Biopreparations
PhD, Head of Laboratory of Immunopharmacology,
Saint-Petersburg
Russian FederationReferences
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