RECEPTOR FUNCTIONS OF SEMA4D IN THE CONTROL OF T-LYMPHOCYTE PROLIFERATION
- Authors: Kuklina E.M.1
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Affiliations:
- “Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
- Issue: Vol 22, No 2-2 (2019)
- Pages: 840-842
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119720
- DOI: https://doi.org/10.31857/S102872210006679-1
- ID: 119720
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Abstract
Сlass IV semaphoring Sema4D is widely represented in the immune system, both in membrane and in soluble form, and controls immune processes, realizing its effects through specific receptors ‒ these are generally accepted ideas. This paper presents data indicating the presence of an alternative way of Sema4D involvingin immunoregulation: this way suggests the functioning of membrane semaphorin as a receptor, which conducts a signal into the cell it is expressed on. Possible signaling mechanisms from membrane Sema4D are discussed.
Keywords
About the authors
E. M. Kuklina
“Institute of Ecology and Genetics of Microorganisms, Ural Branch, Russian Academy of Sciences”
Author for correspondence.
Email: ibis_07@mail.ru
Doctor of Biology, Leading Researcher, Laboratory of Immunoregulation,
Perm
Russian FederationReferences
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