THE ROLE OF MACROPHAGES IN REGENERATION OF MUSCLE TISSUE INDUCED BY ALLOGENIC BIOMATERIAL
- Authors: Lebedeva A.I.1,2, Muslimov S.A.1,2, Afanasiev S.A.3, Kondratieva D.S.3
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Affiliations:
- Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry
- Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
- Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
- Issue: Vol 22, No 2-2 (2019)
- Pages: 849-851
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119747
- DOI: https://doi.org/10.31857/S102872210006676-8
- ID: 119747
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Abstract
Allogeneic biomaterials (AB) after implantation in a defect in the calf muscles of rats and the uterine horn of the rat contribute to the regeneration of tissues due to migration of M1 macrophages expressing Pro-inflammatory factors, TNFα, IL-1. They inhibit the migration of M2 macrophages, fibrosis factors, promote migration and differentiation of myocytes. IN ischemic damaged myocardium after AB implantation, on the contrary, cd68 macrophage deficiency was found, but high expression by Timp2 cells compared to the control, which could contribute to the reduction of scar area. After the introduction of AB in muscle tissues revealed resident macrophages with phenotype IL-1+/CD68+/PCNA+/Hale+/ vimentin+/FGF1- /TGF-β1–.
Keywords
About the authors
A. I. Lebedeva
Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry;Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
Author for correspondence.
Email: jeol02@mail.ru
BD, PhD, senior research assistant of the Department of morphology,
Ufa
Russian FederationS. A. Muslimov
Federal State Budgetary Institution «The Russian Eye and Plastic Surgery Centre» of the Russian Federation Health Ministry;Federal State Budgetary Education Institution «Bashkir State Medical University» of the Russian Federation Health Ministry
MD, PhD, Prof.,
Ufa
Russian FederationS. A. Afanasiev
Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
MD, PhD, Prof.,
Tomsk
Russian FederationD. S. Kondratieva
Federal State Budgetary Research Institute of Cardiology, Tomsk National Research Medical Centre
PhD in Biology, research associate,
Tomsk
Russian FederationReferences
- Muldashev E. R., Muslimov S. A., Musina L. A., Nigmatullin R. T., Lebedeva A. I., Shangina O. R., Khasanov R. A. The role of macrophages in the tissues regeneration stimulated by the biomaterials. Cell Tissue Bank. 2005; 6(2): 99–107.
- Lavine K. J., Epelman S., Uchida K., Weber K. J., Nichols C. G., Schilling J. D., Ornitz D. M., Randolph G. J., Mann D. L. Distinct macrophage lineages contribute to disparate patterns of cardiac recovery and remodeling in the neonatal and adult heart. PNAS. 2014. 111 (45):16029–16034.
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