EXPERIMENTAL MODEL FOR THE STUDY OF A INDEPENDENT FROM THE LYMPHOCYTES OF POLARIZATION INTESTINAL MACROPHAGES IN THE MICE
- Authors: Litvinova E.A.1,2, Achasova K.M.2,1
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Affiliations:
- Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
- The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- Issue: Vol 22, No 2-2 (2019)
- Pages: 852-854
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119755
- DOI: https://doi.org/10.31857/S102872210006651-1
- ID: 119755
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Abstract
Acute inflammatory begins to activate of M1-macrophage by classical pathway. In the chronic form of the disease, the body triggers an adaptive alternative pathway to activate of M2-macrophages. For example, the number of intestinal M2-macrophages increases in infl ammatory bowel disease (IBD) of a chronic form. We have got a model of mice that do not have mature lymphocytes and these animals development of IBD due to the absence of a intestinal mucosal barrier. We obtained a good model that reveals the role of macrophages and lymphocytes in the development of IBD, and can also be used to understand the effect of pharmacological drugs that cause polarization of macrophages.
Keywords
About the authors
E. A. Litvinova
Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences;The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: dimkit@mail.ru
leading researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis;
senior researcher in the laboratory of genetics of laboratory animals,
Novosibirsk
Russian FederationK. M. Achasova
The Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences;Siberian Federal Scientific Centre of Agro-BioTechnologies of the Russian Academy of Sciences
Email: fake@neicon.ru
PhD student in the laboratory of genetics of laboratory animals;
junior researcher in the laboratory for regulation of agricultural animals and plants microbiocenosis,
Novosibirsk
Russian FederationReferences
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