METABOLIC REPROGRAMMING OF MACROPHAGES ACTIVATED BY A NOD1 RECEPTOR AGONIST

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Abstract

We provide the fi rst characterization of glucose and energy metabolism rearrangements in human macrophages upon their activation with a NOD1 receptor agonist (N-acetyl-D-muramyl-L-alanylD-isoglutamyl-meso-diaminopimelic acid, or M-triDAP) in comparison with the eff ects of a TLR4 agonist, lipopolysaccharide (LPS). We demonstrate possibilities of modulation of cytokine production by macrophages using glycolysis inhibitors.

About the authors

M. V. Pashenkov

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Author for correspondence.
Email: mvpashenkov@yandex.ru

Doctor of medical sciences, Acting head of the Laboratory of Clinical Immunology,

Moscow

Russian Federation

N. E. Murugina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

junior researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

A. S. Budikhina

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

P. V. Maximchik

Lomonosov Moscow State University

PhD, researcher, Faculty of Fundamental Medicine, 

 

Russian Federation

Y. A. Dagil

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

L. S. Balyasova

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

junior researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

V. V. Murugin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

PhD, researcher, Laboratory of Clinical Immunology,

Moscow

Russian Federation

G. Z. Chkadua

FSBI “N. N. Blokhin National Medical Research Center of Oncology” of the Ministry of Health of the Russian Federation

PhD, senior researcher, Laboratory of experimental diagnostics and biotherapy of tumors,

Moscow

Russian Federation

B. V. Pinegin

National Research Center “Institute of Immunology” of the Federal Medical-Biological Agency of Russia

Professor, Doctor of medical sciences, Head of the Department of immunodiagnostics and immunocorrection,

Moscow

Russian Federation

References

  1. O’Neill L. A., Pearce E. J. Immunometabolism governs dendritic cell and ma.crophage function. J Exp Med 2015, 213, 15–23.
  2. Jha A. K., Huang S. C., Sergushichev A., Lampropoulou V., Ivanova Y., Loginicheva E., Chmielewski K., Stewart K. M., Ashall J., Everts B., Pearce E. J., Driggers E. M., Artyomov M. N. Network integration of parallel metabolic and transcriptional data reveals metabolic modules that regulate macrophage polarization. Immunity 2015, 42 (3), 419–430.

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Copyright (c) 2019 Pashenkov M.V., Murugina N.E., Budikhina A.S., Maximchik P.V., Dagil Y.A., Balyasova L.S., Murugin V.V., Chkadua G.Z., Pinegin B.V.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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