EFFECTS OF ACUTE COLD STESS ON IFNγ AND IL-12 PRODUCTION BY MICE SPLENOCYTES
- Authors: Sharav’eva I.L.1, Tendryakova S.P.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, UB RAS
- Perm State University
- Issue: Vol 22, No 2-2 (2019)
- Pages: 972-974
- Section: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/120101
- DOI: https://doi.org/10.31857/S102872210006500-5
- ID: 120101
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Abstract
The effect of cold stress on the production of reactive oxygen species (ROS) and IFN-γ and IL-12 was studied 6 hours after the end of stress. It was established that acute cold stress (–20 °C for 60 min) led to increased spontaneous and zymosan-stimulated production of ROS by mouse peritoneal cavity cells 6 hours after the end of stress exposure. In similar experimental conditions, the levels of interferon-γ in spontaneous splenocytes mice increased, while in stimulated mice decreased.
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About the authors
I. L. Sharav’eva
Institute of Ecology and Genetics of Microorganisms, UB RAS
Author for correspondence.
Email: irin.sh@gmail.com
PhD, recercher of the laboratory of biochemistry of development of microorganisms,
Perm
Russian FederationS. P. Tendryakova
Institute of Ecology and Genetics of Microorganisms, UB RAS;Perm State University
Email: fake@neicon.ru
PhD, senior recercher of the laboratory of ecological immunology;
docent Department of microbiology and immunology,
Perm
Russian FederationReferences
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