CINETIDINE – CYTOKINES, ANTIBACTERIAL AND ANTIVIRAL ACTIVITY
- 作者: Zurochka V.A.1,2, Zurochka A.V.1,2, Fomina L.O.1, Dobrynina M.A.1, Zabkov O.I.1, Gritsenko V.A.3
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隶属关系:
- Institute of Immunology and Physiology UrB RAS
- South-Ural State University (National Research University)
- Institute of Cellular and Intracellular Symbiosis UrB RAS
- 期: 卷 22, 编号 2-2 (2019)
- 页面: 781-783
- 栏目: ORIGINAL ARTICLES
- URL: https://journal-vniispk.ru/1028-7221/article/view/119569
- DOI: https://doi.org/10.31857/S102872210006700-5
- ID: 119569
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全文:
详细
Purpose. To analyze the nature of the influence of the synthetic peptide of the active center of granulocyte-macrophage colony stimulating factor (GM-KSF) – ZP2 on the growth in the liquid nutrient medium and biofilm formation of Museum and clinical strains of bacteria, antiviral activity in vitro and in vivo.
Results. It was shown that the peptide of the active center GM-KSF has a pronounced antibacterial effect on a wide range of gram-positive and gram-negative bacteria, reducing the growth of biofilm formation and biomass of bacteria, and the created cosmetic drug ACEGRAM has a similar effect. At the same time sredstva has a strong antiviral dacvim against DNA- and RNA-containing viruses in vitro and in vivo.
Conclusion. Created with synthetic peptide cosmetics Acegram spray and gel have strong antibacterial and antiviral properties in vivo and can be recommended for the treatment of lesions of skin and mucous bacteria and viruses and the peptide that generated the funds is in their mechanisms of action and properties of classical kinocidinum.
作者简介
V. Zurochka
Institute of Immunology and Physiology UrB RAS;South-Ural State University (National Research University)
编辑信件的主要联系方式.
Email: v_zurochka@mail.ru
MD, senior scientific researcherof the laboratory of immunology of inflammation;
professor of the Department of food and biotechnology,
Chelyabinsk
俄罗斯联邦A. Zurochka
Institute of Immunology and Physiology UrB RAS;South-Ural State University (National Research University)
Email: fake@neicon.ru
MD, professor, leader researcher of the laboratory of immunology of inflammation;
professor of the Department of food and biotechnology,
Chelyabinsk
俄罗斯联邦L. Fomina
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
post-graduate student of the Institute of immunology and physiology,
Ekaterinburg
俄罗斯联邦M. Dobrynina
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
Junior scientific researcherof the laboratory of immunology of inflammation,
Ekaterinburg
俄罗斯联邦O. Zabkov
Institute of Immunology and Physiology UrB RAS
Email: fake@neicon.ru
post-graduate student,
Ekaterinburg
俄罗斯联邦V. Gritsenko
Institute of Cellular and Intracellular Symbiosis UrB RAS
Email: fake@neicon.ru
MD, Professor, head of the laboratory,
Orenburg
俄罗斯联邦参考
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- Зурочка А. В., Зурочка В. А., Добрынина М. А., Зуева Е. Б., Дукардт В. В., Гриценко В. А., Тяпаева Я. В., Черешнев В. А. Феномен наличия уникальной комбинации иммунобиологических свойств у синтетического аналога активного центра гра ну ло цитар но-макрофагального колониестимулирующего фактора (ГМ-КСФ). Бюллетень Оренбургского научного центра УрО РАН. 2016. 2: 30c. [Электр. ресурс] (URL: http://elmag.uran.ru:9673/magazine/Numbers/2016-2/Articles/ZAV-2016-2.pdf).
- Справочник по микробиологическим и вирусологическим методам исследования /Под ред. М. О. Биргера. М.: Медицина, 1982. 464 с.
- Бухарин О. В., Гриценко В. А. Влияние in vitro препарата лейкоцитарного катионного белка “Интерцид” на Escherichia coli. Антибиот. и химиотер. 2000. 45 (1): 16–20.
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