卷 18, 编号 2 (2013)
- 年: 2013
- 文章: 12
- URL: https://journal-vniispk.ru/1028-9984/issue/view/2371
Articles
COMPARATIVE EVALUATION OF DIFFERENT REGIMEN OF PLATINUM-BASED CHEMOTHERAPY IN TREATMENT OF ADVANCED SMALL CELL LUNG CANCER (experience of chemotherapy department N.N.Blokhin Russian Cancer Research Center RAMS)
摘要
The article reviews the experience of chemotherapy department N.N.Blokhin Russian Cancer Recearch Center RAMS from 1996 to 2012 in the treatment of SCLC patients with combinations of cytotoxic drugs cisplatin and carboplatin. The efficiency of different schemes on the basis of platinum with etoposide, irinotecan, docetaxel, ACNU (EP, IP, DP, AVP)has been studied. The data on the mode of treatment, side effects, and survival after these treatment schemes. Maximum efficiency was shown by EP, IP, AVP schemes.
Russian Journal of Oncology. 2013;18(2):4-10
4-10
DEVELOPMENT OF INTRAVENOUS ADMINISTRATION OF L-LYSINE-ALPHA-OXIDASE FROM TRICHODERMA CF. AUREOVIRIDE RIFAI BKMF-4268 REGIME CONTROLLED BY SAFETY AND EFFICACY OF TREATMENT
摘要
Various doses and modes of intravenous L-lysine-alpha-oxidase application on tumor models in mice under the control of efficacy and tolerability have been studied. Optimal choice scheme provides introduction of the first relatively high starting dose and subsequent maintenance doses comprising А or % of the first ("discrete" mode). The efficiency and an acceptable tolerability has been shown during "discrete" 5-fold treatment course with intravenous cumulative doses of 450-550 U/kg. By treating L-lysine-alpha-oxidase in the "discrete" mode following tumor-bearing mice have been sensitive: breast adenocarcinoma Sa755, B16 melanoma, adenocarcinoma of the colon AKATOL, cervical cancer, cervical 5, epidermoid carcinoma and Lewis lung plasmacytoma CI-406 (TROmax = 57-92%).
Russian Journal of Oncology. 2013;18(2):10-14
10-14
FLUORESCENCE DIAGNOSIS AND PHOTODYNAMIC THERAPY OF MALIGNANT GLIOMAS IN RATS
摘要
The possibilities of fl uorescence diagnosis (FD) and photodynamic therapy (PDT) with domestic photosensitizers and domestic equipment in brain tumors have been studied. Investigation of the level and selectivity of accumulation dynamics of Photosens and Tiosens in C6 glioma tissue by spectral fl uorescence method has showed the selective accumulation of both agents in tumor tissue. High effi ciency of PDT with Photosens and Tiosens both as monotherapy and as combined treatment has been shown on the base of pathomorphological criteria. Increase of therapeutic effi cacy of combined treatment of C6 glioma using FD and intraoperative PDT with Alasens has been established.
Russian Journal of Oncology. 2013;18(2):14-18
14-18
INFLUENCE OF PREGNA-D’-PENTARANES ON CELL CULTURES HELA AND MONONUCLEAR CELL FRACTION OF PERIPHERAL BLOOD
摘要
The aim of the study. The study of the binding pregna-D’-pentaran with progesterone receptors in the mononuclear cell fraction of peripheral blood (MNFK) and cell culture HeLa, assessment of the compounds impact on cells of these cultures and the level of TNF-alpha in MNFK. Material and methods. Blood samples were taken from 32 patients with uterine cancer (average age 36,8 ± 0,78 years), peripheral blood MNFK isolated by Boyum. To assess the binding activity of the test compounds using the method of radioligand analysis. Steroids (50 nM) were incubated with MNFK within 72 hours and the amount of cytokines using ELISA kits ("Vector-Best") for instructions. Pentaranov impact on cell viability was assessed by MTT assay. Statistical processing was performed using Statsoft Statistica software and MS Excel. Results. All studied pregna-D’-pentaran exhibit relatively high affinity for ER and HeLa cells MNFK, especially IV, III, who had practically no effect on the viability MNFK and effectively inhibited the growth of HeLa cells. These compounds also stimulate the production of immune cells cytokine TNF-alpha. Conclusions. From 6 representatives of pregna-D’-pentaran we found two of the most promising compounds - (HI-873) and 16a, 17a-cyclohexanol-5aH-pregnan-3 ,20-dione (IV-to-100). These compounds with maximum inhibition of HeLa cell viability do not have a cytostatic effect on the immune cells and stimulate the production of the latest cytotoxic cytokine TNF-alpha.
Russian Journal of Oncology. 2013;18(2):18-22
18-22
ENDOTHELIAL DYSFUNCTION AND SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IN PATIENTS WITH PANCREATIC HEAD CANCER
摘要
The purpose of the study - to determine the degree of endothelial dysfunction in the dynamics of the perioperative period in patients with cancer of the pancreatic head in relation to the development and course of systemic inflammatory response syndrome. A total of 42 patients with cancer of the pancreatic head, underwent radical surgery. The parameters of the vascular endothelium: the number of circulating endothelial cells, the content of NO metabolites in blood and excretion, the content of von Willebrand factor in the blood, the level of endothelium-dependent vasodilation, the development of systemic inflammatory response syndrome have been determined. It has been revealed that the presence of endothelial dysfunction signs before surgical intervention corresponds to an increase risk of systemic inflammatory response after surgery was significantly correlated with its constituent symptoms.
Russian Journal of Oncology. 2013;18(2):22-26
22-26
REASONABILITY OF THE PRIMARY TUMOR REMOVAL IN METASTATIC BREAST CANCER PATIENTS AT INITIAL PRESENTATION
摘要
Treatment of patients with newly diagnosed metastatic breast cancer is based on the drug and radiation therapy. Extraction of the primary tumor is generally not recommended. We examined the effects of surgical treatment on survival of 91 patients with metastatic primary breast cancer observed in the RCRC. NN Blokhin, for the period from 1999 to 2009. All women received systemic therapy with or without radiation therapy. Excision of the primary tumor was performed in 91 cases, in 106 cases (control group) the operation was not performed. Removal of the primary tumor in patients with primary - metastatic breast cancer with ECOG 0-1 has shown to be an independent prognostic factor, which significantly improves overall survival and progression-free survival. Multivariate analysis revealed a significant increase in overall survival and progression-free survival in those cases where the operation was carried out after successful systemic therapy with achievement of partial response, compared with those who underwent surgery in the first stage (p < 0,05). In addition, the long-term results of surgical treatment of patients with newly diagnosed metastatic breast cancer affect the number of metastases, the number of affected organs and positive hormone receptor status of the tumor (p < 0.05). However, given the many other factors that can affect the long-term results of surgical treatment of patients with primary metastatic breast cancer, it is advisable to conduct a prospective study.
Russian Journal of Oncology. 2013;18(2):27-31
27-31
THE DATA OF DNA- FLOW CYTOMETRY IN PROGNOSIS OF CERVIX CANCER
摘要
The purpose of research - the study of quantitative cell cervical cancer (CC) due to radiation therapy: ploidy and their distribution over the phases of the cell cycle analysis of the relationship of these parameters with clinical prognosis factors. Presents the group of 121 patients with CC II, III, IV stages, where the courses combined radiotherapy were from 2000 to 2008. Biopsy tumor samples were used during the radiotherapy. Diploid tumors were detected in 38 (31.4%) patients, aneuploid - in 75 (62%), tetraploid - in 7 (5.8%) and 1 (0.8%) - gyperaneuploid tumor. Overall and disease free-5-year survival in diploid tumors was higher (68,4 ± 9,6% and 45,1 ± 11,0%) compared to the aneuploid (45,4 ± 8,4% and 32.7 ± 7,2%), p <0.05. Among aneuploid CC recurrence rate is higher than the diploid: 24.0% versus 2.6% (p <0.05), respectively. Aneuploid CC with S phase fraction <7% associated with better overall and disease-free survival within 5 years was 57,2 ± 13,1% and 45,6 ± 11,3%, than those with S-phase fraction 7%- > 14 % - 32,3 ± 10,3% and 18,2 ± 8,5% (p = 0.03 and p = 0.0006), respectively. For S-phase fraction ≥ 14% of all patients died within the 1st year follow-up of disease progression. Similarly, in a group of diploid tumors disease free-5-year survival (p = 0.002) with a low content of cells in S phase was 74,7 ± 10,1% of patients. When S-phase fraction > 7%, all patients died within 3 years of the progression of the disease. With increasing stage of cervical cancer, increased proliferative activity of aneuploid tumors. Disease-free survival was worse with increasing PI (p = 0.01). In patients with cervical cancer stage III - IV at age <49 years, the main prognostic factors include poor differentiated squamous cancer, PI of 15 to 20%, IDNA within 1.1 - 1.84 and more. In patients > 49 years - PI over 20% and IDNA 0.6 - 0.8. In this category of patients the course of chemo-radiotherapy is appropriate. Both ploidy and number of cells in S phase should be seen as independent prognostic criteria in patients with stage II CC.
Russian Journal of Oncology. 2013;18(2):31-37
31-37
ULTRA-HIGH FREQUENCY RADIOTHERMAL MAMMOGRAPHY IN NEOADJUVANT BREAST CANCER THERAPY EFFECT EVALUATION
摘要
Ultra-high frequency radio thermal mammography permits thermal changes to be estimated both within the breast and onto its surface. Due to its simplicity, non-invasiveness and safety, decametric microwave radio-thermometry may be a promising method for diagnosing breast cancer and evaluating the efficiency of its treatment.
Russian Journal of Oncology. 2013;18(2):37-40
37-40
DIFFICULTIES IN THE DIAGNOSIS OF APPENDIX CANCER: A CLINICAL REPORT
摘要
A clinical case of appendix cancer in 68-year-old woman, earlier operated for metastatic ovarian tumor is described. The professional diagnostic approach (immunohistochemical morphology and re-colonoscopy) could help identify appendix cancer and changed treatment algorithm for secondary radical surgery.
Russian Journal of Oncology. 2013;18(2):40-42
40-42
MALIGNANT NEOPLASMS IN THE POPULATION OF BURYATIA REPUBLIC
摘要
The anlysis of the malignant neoplasms morbidity in the Republic of Buryatia over a long period of time (25 years) without subdivision on location has been performed. From 1987 to 2011, a high growth of cancer pathology has been identified, which the author relates to unfavorable ecological environment, especially with the high background radiation in the Trans-Baikal region, due to bedrock, mountainous terrain, creating a so-called "hollows effect" and the presence of strong uranium, gold, ores and building materials. Based on the standardized indicators of the oncological morbidity for the last 10 years (2000-2010), the maps of the cancer pathology risk in the population of the administrative regions in the Republic of Buryatia for management and preventive measures for its prevention have been drawn. Pre-existing card as a result of morbidity external testing for the period (1996-2005) has undergone significant changes, indicating its significant growth.
Russian Journal of Oncology. 2013;18(2):42-46
42-46
RADIATION DETECTION OF BREAST CANCER IN WOMEN WITH A GENETIC PREDISPOSITION OR FAMILY HISTORY (REVIEW)
摘要
Screening of breast cancer with mammography recommended to women below the age of 40 years old has been shown to decrease mortality from breast cancer. But there is group of young women with high risk for developing breast cancer. The main part of this group are women with BRCA 1/2 mutations and women with strong family histories without known BRCA 1/2 mutations. Mammography has much lower accuracy in women under 40 years especially genetic mutation carriers compared to sporadic cases of breast cancer. For this reason there is necessity in new screening methods of young high-risk women to detect early-stage cancers.
Russian Journal of Oncology. 2013;18(2):46-54
46-54
AKADEMIK NIKOLAY NIKOLAEVICh TRAPEZNIKOV (k 85-letiyu so dnya rozhdeniya)
Russian Journal of Oncology. 2013;18(2):55-56
55-56