Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application
- Autores: Garashchenko B.L.1, Korsakova V.A.1, Yakovlev R.Y.2,3
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Afiliações:
- Department of High Energy Chemistry and Radioecology
- Vernadsky Institute of Geochemistry and Analytical Chemistry
- Ryazan State Medical University
- Edição: Volume 81, Nº 10 (2018)
- Páginas: 1515-1525
- Seção: Medical Physics and Biophysics
- URL: https://journal-vniispk.ru/1063-7788/article/view/193973
- DOI: https://doi.org/10.1134/S1063778818100071
- ID: 193973
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Resumo
In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.
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Sobre autores
B. Garashchenko
Department of High Energy Chemistry and Radioecology
Autor responsável pela correspondência
Email: bogdan@garashchenko.com
Rússia, Miusskaya pl. 9, Moscow, 125047
V. Korsakova
Department of High Energy Chemistry and Radioecology
Email: bogdan@garashchenko.com
Rússia, Miusskaya pl. 9, Moscow, 125047
R. Yakovlev
Vernadsky Institute of Geochemistry and Analytical Chemistry; Ryazan State Medical University
Email: bogdan@garashchenko.com
Rússia, ul. Kosygina 19, Moscow, 119991; ul. Vysokovol’tnaya 9, Ryazan, 390026
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