Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application


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Resumo

In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.

Sobre autores

B. Garashchenko

Department of High Energy Chemistry and Radioecology

Autor responsável pela correspondência
Email: bogdan@garashchenko.com
Rússia, Miusskaya pl. 9, Moscow, 125047

V. Korsakova

Department of High Energy Chemistry and Radioecology

Email: bogdan@garashchenko.com
Rússia, Miusskaya pl. 9, Moscow, 125047

R. Yakovlev

Vernadsky Institute of Geochemistry and Analytical Chemistry; Ryazan State Medical University

Email: bogdan@garashchenko.com
Rússia, ul. Kosygina 19, Moscow, 119991; ul. Vysokovol’tnaya 9, Ryazan, 390026

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