Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application


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In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.

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B. Garashchenko

Department of High Energy Chemistry and Radioecology

编辑信件的主要联系方式.
Email: bogdan@garashchenko.com
俄罗斯联邦, Miusskaya pl. 9, Moscow, 125047

V. Korsakova

Department of High Energy Chemistry and Radioecology

Email: bogdan@garashchenko.com
俄罗斯联邦, Miusskaya pl. 9, Moscow, 125047

R. Yakovlev

Vernadsky Institute of Geochemistry and Analytical Chemistry; Ryazan State Medical University

Email: bogdan@garashchenko.com
俄罗斯联邦, ul. Kosygina 19, Moscow, 119991; ul. Vysokovol’tnaya 9, Ryazan, 390026

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