Radiopharmaceuticals Based on Alpha Emitters: Preparation, Properties, and Application
- 作者: Garashchenko B.L.1, Korsakova V.A.1, Yakovlev R.Y.2,3
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隶属关系:
- Department of High Energy Chemistry and Radioecology
- Vernadsky Institute of Geochemistry and Analytical Chemistry
- Ryazan State Medical University
- 期: 卷 81, 编号 10 (2018)
- 页面: 1515-1525
- 栏目: Medical Physics and Biophysics
- URL: https://journal-vniispk.ru/1063-7788/article/view/193973
- DOI: https://doi.org/10.1134/S1063778818100071
- ID: 193973
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详细
In this review, the problems of the development of radiopharmaceuticals (RPs) based on alphaemitting radionuclides are discussed. The prospects of application of the radionuclides 227Th, 225Ac, 223Ra, 213Bi, 212Pb/212Bi, 212Bi, 211At, and 149Tb are estimated in the aspect of their physicochemical properties, such as half-life, properties of daughter radionuclides, and complexing ability. The methods used for the production of radionuclides and their industrial availability are considered. Some examples of radionuclide complexes with ligands and nanoparticles for targeted delivery are presented. The results of medical trials for RPs based on alpha emitters are given.
作者简介
B. Garashchenko
Department of High Energy Chemistry and Radioecology
编辑信件的主要联系方式.
Email: bogdan@garashchenko.com
俄罗斯联邦, Miusskaya pl. 9, Moscow, 125047
V. Korsakova
Department of High Energy Chemistry and Radioecology
Email: bogdan@garashchenko.com
俄罗斯联邦, Miusskaya pl. 9, Moscow, 125047
R. Yakovlev
Vernadsky Institute of Geochemistry and Analytical Chemistry; Ryazan State Medical University
Email: bogdan@garashchenko.com
俄罗斯联邦, ul. Kosygina 19, Moscow, 119991; ul. Vysokovol’tnaya 9, Ryazan, 390026
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