Email this article Hydroxamic acids: synthesis and adjuvant activity in combinatorial anticancer therapy
- Authors: Fedorov B.S.1, Fadeev M.A.1, Eremeev A.B.1, Konovalova N.P.1, Bogdanov G.N.1, Tatyanenko L.V.1, Sashenkova T.E.1, Mishchenko D.V.1
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Issue: Vol 65, No 3 (2016)
- Pages: 801-805
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/237682
- DOI: https://doi.org/10.1007/s11172-016-1377-0
- ID: 237682
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Abstract
Monoand disubstituted N-hydroxyamides of dicarboxylic acids were prepared by reaction of dicarboxylic acids or acid anhydrides with hydroxylamine. The use of these compounds in combinatorial cytostatic therapy of implanted tumors with cisplatin or cyclophosphamide totally inhibits metastasis formation in B16 melanoma and Lewis lung carcinoma, and resulted in 100% survival of leukemic animals.
About the authors
B. S. Fedorov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
M. A. Fadeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
A. B. Eremeev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
N. P. Konovalova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
G. N. Bogdanov
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
L. V. Tatyanenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
T. E. Sashenkova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
D. V. Mishchenko
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: boris-45@inbox.ru
Russian Federation, 1 prosp. Akad. N. N. Semenova, Chernogolovka, Moscow Region, 142432
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