Email this article Effect of natural polysaccharides and oligosaccharides on the permeability of cell membranes
- Authors: Selyutina O.Y.1, Apanasenko I.E.1, Shilov A.G.2, Khalikov S.S.3, Polyakov N.E.1
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Affiliations:
- V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences
- Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Issue: Vol 66, No 1 (2017)
- Pages: 129-135
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/239880
- DOI: https://doi.org/10.1007/s11172-017-1710-2
- ID: 239880
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Abstract
Glycyrrhizic acid, arabinogalactan, and β-cyclodextrin are capable of forming complexes with various drug compounds significantly enhancing their solubility and bioavailability. To elucidate the mechanism of action of oligo- and polysaccharides, the exchange time of transporting formate ions through the membrane of myeloblastic leukemia cells (K562) was measured by NMR spectroscopy with the addition of paramagnetic ions. It was found that glycyrrhizic acid and arabinogalactan substantially increased the membrane permeability.
About the authors
O. Yu. Selyutina
V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences
Author for correspondence.
Email: olga.gluschenko@gmail.com
Russian Federation, 3 ul. Institutskaya, Novosibirsk, 630090
I. E. Apanasenko
V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences
Email: olga.gluschenko@gmail.com
Russian Federation, 3 ul. Institutskaya, Novosibirsk, 630090
A. G. Shilov
Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Email: olga.gluschenko@gmail.com
Russian Federation, 10 prosp. Akad. Lavrent´eva, Novosibirsk, 630090
S. S. Khalikov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: olga.gluschenko@gmail.com
Russian Federation, 28 ul. Vavilova, Moscow, 119991
N. E. Polyakov
V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences
Email: olga.gluschenko@gmail.com
Russian Federation, 3 ul. Institutskaya, Novosibirsk, 630090
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