Synthesis and structure of (het)arylglutamic acids and pyroglutamic acid hydrazides

O. S. Vasil´eva; B. M. Berestovitskaya; I. N. Tyurenkov; E. S. Ostroglyadov; V. N. Perfilova; N. V. Gorodnicheva; A. I. Yaremchuk

doi:10.1007/s11172-017-1913-6

Synthesis and structure of (het)arylglutamic acids and pyroglutamic acid hydrazides

Authors: Vasil´eva O.S.¹, Berestovitskaya B.M.¹, Tyurenkov I.N.², Ostroglyadov E.S.¹, Perfilova V.N.², Gorodnicheva N.V.¹, Yaremchuk A.I.¹
Affiliations:
1. A. I. Herzen State Pedagogical University of Russia
2. Volgograd State Medical University
Issue: Vol 66, No 8 (2017)
Pages: 1491-1496
Section: Full Articles
URL: https://journal-vniispk.ru/1066-5285/article/view/241128
DOI: https://doi.org/10.1007/s11172-017-1913-6
ID: 241128

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Abstract

Hydrochlorides of (2R*,3R*)-3-(het)arylglutamic acid diesters were synthesized by esterification of the corresponding glutamic acids (Glu). Diesters reacted with hydrazine hydrate to give (4R*,5R*)-2-pyrrolidone-5-carboxylic acid hydrazides. Hydrochlorides of glutamic acids diesters were found to exhibit cardioprotective properties against acute and chronic stress myocardial damage.