NO-donating and hemolytic activity of tetranitrosyl iron complexes with ligands of the 2-mercaptopyridine series


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Abstract

The NO-donating and hemolytic activity of the binuclear tetranitrosyl iron complexes (TNIC) with thiolate ligands of the composition [Fe2(SR)2(NO)4], where R is pyridin-2-yl and 5-nitropyridin-2-yl, was studied. The NO-donating and hemolytic activities of the com- plex with the nitrosubstituted ligand are approximately two and three times higher than the corresponding characteristics of the complex with unsubstituted 2-mercaptopyridine, respectively. Symbate changes in these parameters confirm the conclusion made earlier on the peroxynitrite-dependent mechanism of erythrocyte hemolysis under the action of TNIC. The NO-donating activity of TNIC with ligands of the 2-mercaptopyridine series, unlike the previously studied complexes containing thioderivatives of other nitrogenous heterocycles as S-ligands, did not decrease with an increase in the concentration of erythrocytes. This allows one to consider them as promising NO-donating substances for the preparation of pharma- cological remedies.

About the authors

N. I. Neshev

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

E. M. Sokolova

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

G. I. Kozub

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

T. A. Kondrat´eva

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

N. A. Sanina

Institute of Problems of Chemical Physics, Russian Academy of Sciences

Author for correspondence.
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432

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