NO-donating and hemolytic activity of tetranitrosyl iron complexes with ligands of the 2-mercaptopyridine series
- Authors: Neshev N.I.1, Sokolova E.M.1, Kozub G.I.1, Kondrat´eva T.A.1, Sanina N.A.1
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Affiliations:
- Institute of Problems of Chemical Physics, Russian Academy of Sciences
- Issue: Vol 66, No 8 (2017)
- Pages: 1510-1514
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/241149
- DOI: https://doi.org/10.1007/s11172-017-1916-3
- ID: 241149
Cite item
Abstract
The NO-donating and hemolytic activity of the binuclear tetranitrosyl iron complexes (TNIC) with thiolate ligands of the composition [Fe2(SR)2(NO)4], where R is pyridin-2-yl and 5-nitropyridin-2-yl, was studied. The NO-donating and hemolytic activities of the com- plex with the nitrosubstituted ligand are approximately two and three times higher than the corresponding characteristics of the complex with unsubstituted 2-mercaptopyridine, respectively. Symbate changes in these parameters confirm the conclusion made earlier on the peroxynitrite-dependent mechanism of erythrocyte hemolysis under the action of TNIC. The NO-donating activity of TNIC with ligands of the 2-mercaptopyridine series, unlike the previously studied complexes containing thioderivatives of other nitrogenous heterocycles as S-ligands, did not decrease with an increase in the concentration of erythrocytes. This allows one to consider them as promising NO-donating substances for the preparation of pharma- cological remedies.
About the authors
N. I. Neshev
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
E. M. Sokolova
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
G. I. Kozub
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
T. A. Kondrat´eva
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
N. A. Sanina
Institute of Problems of Chemical Physics, Russian Academy of Sciences
Author for correspondence.
Email: sanina@icp.ac.ru
Russian Federation, 1 prosp. Akad. Semenova, Chernogolovka, Moscow Region, 142432
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