Conjugation of indole derivatives by copper-catalyzed alkyne-azide cycloaddition

V. B. Sokolov; А. Yu. Aksinenko; Т. А. Epishina; Т. V. Goreva; S. О. Bachurin

doi:10.1007/s11172-017-1931-4

Conjugation of indole derivatives by copper-catalyzed alkyne-azide cycloaddition

Authors: Sokolov V.B.¹, Aksinenko А.Y.¹, Epishina Т.А.¹, Goreva Т.V.¹, Bachurin S.О.¹
Affiliations:
1. Institute of Physiologically Active Compounds, Russian Academy of Sciences
Issue: Vol 66, No 9 (2017)
Pages: 1607-1610
Section: Full Articles
URL: https://journal-vniispk.ru/1066-5285/article/view/241223
DOI: https://doi.org/10.1007/s11172-017-1931-4
ID: 241223

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Abstract

An efficient synthetic procedure to combine biologically active indole derivatives by the triazole-containing spacer in a molecule has been proposed. The procedure was based on a copper-catalyzed alkyne-azide cycloaddition of azide-containing carbazoles and N-propargyl-containing carbazoles, tetrahydrocarbazoles, and tetrahydro-γ-carbolines.