Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles
- 作者: Spasov A.A.1,2, Zhukovskaya O.N.3, Brigadirova A.A.1,2, Abbas H.S.3, Anisimova V.A.3, Sysoeva V.A.1, Rashchenko A.I.1, Litvinov R.A.1, Mayka O.Y.1, Babkov D.A.1, Morkovnik A.S.3
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隶属关系:
- Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
- Volgograd Medical Scientific Center
- Institute of Physical and Organic Chemistry, Southern Federal University
- 期: 卷 66, 编号 10 (2017)
- 页面: 1905-1912
- 栏目: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/241466
- DOI: https://doi.org/10.1007/s11172-017-1965-7
- ID: 241466
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详细
An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.
作者简介
A. Spasov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center
编辑信件的主要联系方式.
Email: aspasov@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090
A. Brigadirova
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131
H. Abbas
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090
V. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090
V. Sysoeva
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131
A. Rashchenko
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131
R. Litvinov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. Mayka
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131
D. Babkov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131
A. Morkovnik
Institute of Physical and Organic Chemistry, Southern Federal University
编辑信件的主要联系方式.
Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090
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