Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles
- Авторлар: Spasov A.A.1,2, Zhukovskaya O.N.3, Brigadirova A.A.1,2, Abbas H.S.3, Anisimova V.A.3, Sysoeva V.A.1, Rashchenko A.I.1, Litvinov R.A.1, Mayka O.Y.1, Babkov D.A.1, Morkovnik A.S.3
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Мекемелер:
- Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
- Volgograd Medical Scientific Center
- Institute of Physical and Organic Chemistry, Southern Federal University
- Шығарылым: Том 66, № 10 (2017)
- Беттер: 1905-1912
- Бөлім: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/241466
- DOI: https://doi.org/10.1007/s11172-017-1965-7
- ID: 241466
Дәйексөз келтіру
Аннотация
An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.
Негізгі сөздер
Авторлар туралы
A. Spasov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center
Хат алмасуға жауапты Автор.
Email: aspasov@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. Zhukovskaya
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
Ресей, 194/2 prosp. Stachki, Rostov-on-Don, 344090
A. Brigadirova
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131
H. Abbas
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
Ресей, 194/2 prosp. Stachki, Rostov-on-Don, 344090
V. Anisimova
Institute of Physical and Organic Chemistry, Southern Federal University
Email: asmork@mail.ru
Ресей, 194/2 prosp. Stachki, Rostov-on-Don, 344090
V. Sysoeva
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131
A. Rashchenko
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131
R. Litvinov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131
O. Mayka
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131
D. Babkov
Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation
Email: asmork@mail.ru
Ресей, 1 pl. Pavshikh Bortsov, Volgograd, 400131
A. Morkovnik
Institute of Physical and Organic Chemistry, Southern Federal University
Хат алмасуға жауапты Автор.
Email: asmork@mail.ru
Ресей, 194/2 prosp. Stachki, Rostov-on-Don, 344090
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