Synthesis and pharmacological activity of 2-(biphenyl-4-yl)imidazo[1,2-a]benzimidazoles


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An efficient method for the synthesis of novel 9H-imidazo[1,2-a]benzimidazole derivatives containing a biphenyl substituent at position 2 was developed. These compounds, belonging to the privileged substructures, have been tested for a wide range of pharmacological activities in the in vitro test panel. It was shown that the synthesized derivatives demonstrated high antioxidant activity, some of them inhibit type 1B protein tyrosine phosphatase, activate AMP-activated protein kinase, possess antiplatelet properties, and a rare and very interesting kind of activity, the ability to break cross-links of glycated proteins. The most active compounds can be suggested for further optimization.

作者简介

A. Spasov

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center

编辑信件的主要联系方式.
Email: aspasov@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131

O. Zhukovskaya

Institute of Physical and Organic Chemistry, Southern Federal University

Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090

A. Brigadirova

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation; Volgograd Medical Scientific Center

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131; 1 pl. Pavshikh Bortsov, Volgograd, 400131

H. Abbas

Institute of Physical and Organic Chemistry, Southern Federal University

Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090

V. Anisimova

Institute of Physical and Organic Chemistry, Southern Federal University

Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090

V. Sysoeva

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131

A. Rashchenko

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131

R. Litvinov

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131

O. Mayka

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131

D. Babkov

Volgograd State Medical University, the Ministry of Healthcare of the Russian Federation

Email: asmork@mail.ru
俄罗斯联邦, 1 pl. Pavshikh Bortsov, Volgograd, 400131

A. Morkovnik

Institute of Physical and Organic Chemistry, Southern Federal University

编辑信件的主要联系方式.
Email: asmork@mail.ru
俄罗斯联邦, 194/2 prosp. Stachki, Rostov-on-Don, 344090

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