Email this article Synthesis of sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin
- Authors: Shchetinina M.A.1, Chernoburova E.I.1, Kolotyrkina N.G.1, Dzhafarov M.K.2, Vasilevich F.I.2, Zavarzin I.V.1
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Affiliations:
- N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
- K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
- Issue: Vol 67, No 5 (2018)
- Pages: 836-839
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/242512
- DOI: https://doi.org/10.1007/s11172-018-2146-z
- ID: 242512
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Abstract
Treatment of ivermectin with sulfuric acid–acetic anhydride in pyridine gives sodium 5-sulfate-ivermectin and disodium 4″,5-disulfate-ivermectin. The synthesized salts are water-soluble compounds with promising antiparasitic activity.
About the authors
M. A. Shchetinina
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
E. I. Chernoburova
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
N. G. Kolotyrkina
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
M. Kh. Dzhafarov
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Russian Federation, 23 ul. Akad. Skryabina, Moscow, 109472
F. I. Vasilevich
K. I. Skryabin Moscow State Academy of Veterinary Medicine and Biotechnology
Email: zavi@ioc.ac.ru
Russian Federation, 23 ul. Akad. Skryabina, Moscow, 109472
I. V. Zavarzin
N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences
Author for correspondence.
Email: zavi@ioc.ac.ru
Russian Federation, 47 Leninsky prosp., Moscow, 119991
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