Synthesis of 3,4-diaryl- and 4-acyl-3-arylpyrroles and study of their antimitotic activity


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

The Barton–Zard reaction of nitro substituted stilbenes and chalcones with ethyl isocyanoacetate afforded 3,4-diaryl- and 4-acyl-3-arylpyrroles, respectively. 3-Arylpyrrole-2,4- dicarboxylates and 4-arylisoxazoline N-oxides were side reaction products. Antimitotic activity of target 3,4-disubstituted pyrroles was studied on a sea urchin embryo model. Pyrroles unsubstituted at positions 2 and 5 were the most active. The activity increased with the number of methoxy groups in the Ar substituent.

Авторлар туралы

A. Samet

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

E. Sil’yanova

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences; D. I. Mendeleev University of Chemical Technology of Russia

Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991; 9 Miusskaya pl., Moscow, 125047

V. Ushkarov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

M. Semenova

N. K. Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences

Email: sametav@ioc.ac.ru
Ресей, 26 ul. Vavilova, Moscow, 119334

V. Semenov

N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences

Email: sametav@ioc.ac.ru
Ресей, 47 Leninsky prosp., Moscow, 119991

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