Email this article Trifluoromethylated 5-aminoderivatives of (indol-3-yl)acetic acid
- Authors: Vorobyeva D.V.1, Vasilyeva T.P.1, Osipov S.N.1
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Affiliations:
- A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
- Issue: Vol 67, No 8 (2018)
- Pages: 1459-1466
- Section: Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/242828
- DOI: https://doi.org/10.1007/s11172-018-2240-2
- ID: 242828
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Abstract
New CF3-containing derivatives of (5-aminoindol-3-yl)acetic acid were synthesized from 5-nitroindole and trifluoropyruvate or 2-diazotrifluoropropionate. Their reactions with isocyanates allowed us to obtain the series of new ureas, including sulfonylureas, containing a pharmacophore moiety of α-(trifluoromethyl)indolylacetic acid.
About the authors
D. V. Vorobyeva
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
T. P. Vasilyeva
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
S. N. Osipov
A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences
Author for correspondence.
Email: osipov@ineos.ac.ru
Russian Federation, 28 ul. Vavilova, Moscow, 119991
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