Мақаланы E-mail арқылы жіберу Kinetic resolution of racemic 3-tert-butyl-3,4-dihydro-2H-[1,4]benzoxazine via acylation with chiral acyl chlorides
- Авторлар: Vakarov S.A.1, Gruzdev D.A.1,2, Chulakov E.N.1, Levit G.L.1,2, Krasnov V.P.1
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Мекемелер:
- I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
- Ural Federal University named after the first President of Russia B. N. Yeltsin
- Шығарылым: Том 68, № 4 (2019)
- Беттер: 841-847
- Бөлім: Full Article
- URL: https://journal-vniispk.ru/1066-5285/article/view/243355
- DOI: https://doi.org/10.1007/s11172-019-2494-3
- ID: 243355
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Аннотация
A comparative study of the kinetic resolution of racemic 3-tert-butyl-3,4-dihydro-2H-[1,4]-benzoxazine through the acylation by various chiral acyl chlorides was carried out. A preparative method for obtaining enantiomerically pure (S)-3-tert-butyl-3,4-dihydro-2H-[1,4]benzoxazine can be based on the acylation with N-phthaloyl-(S)-phenylalanyl or (R)-2-phenoxypropionyl chlorides, followed by the acid hydrolysis of the corresponding diastereomerically pure amides.
Авторлар туралы
S. Vakarov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: savakarov@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
D. Gruzdev
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: savakarov@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
E. Chulakov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: savakarov@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
G. Levit
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Ural Federal University named after the first President of Russia B. N. Yeltsin
Email: savakarov@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002
V. Krasnov
I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
Email: savakarov@ios.uran.ru
Ресей, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990
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