Отправить статью по E-mail Copper complexes: cytotoxicity and transport possibilities
- Авторы: Orlova M.A.1,2,3, Trofimova T.P.1,4, Zolotova N.S.1, Ivanov I.A.1, Spiridonov V.V.1, Proshin A.N.4, Borodkov A.S.5, Yaroslavov A.A.1, Orlov A.P.1
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Учреждения:
- Department of Chemistry, M. V. Lomonosov Moscow State University
- Department of Biochemistry and Pharmacology, Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology
- N. I. Pirogov Russian National Research Medical University
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- A. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
- Выпуск: Том 68, № 10 (2019)
- Страницы: 1933-1939
- Раздел: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/243510
- DOI: https://doi.org/10.1007/s11172-019-2649-2
- ID: 243510
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Аннотация
A copper complex with N-(5,6-dihydro-4H-1,3-thiazin-2-yl)benzamide was synthesized for the first time and characterized by 1H NMR spectroscopy, LETDY mass spectrometry, and elemental analysis. A comparative study of the obtained complex and copper 2-aminopyrimidine complex was performed by flow cytometry on normal lymphocytes and Jurkat cells. Complexes with radionuclides 64,67Cu (with and wihout a carrier) were prepared, and distribution of the labeled complexes in the organs of mice was considered. Packing in carboxymethylcellulose-based microgels was proposed as a transport form for the complexes. The results show a promise of the obtained materials as potential radiopharmaceutical agents.
Об авторах
M. Orlova
Department of Chemistry, M. V. Lomonosov Moscow State University; Department of Biochemistry and Pharmacology, Dmitry Rogachev National Medical Research Center for Pediatric Hematology, Oncology, and Immunology; N. I. Pirogov Russian National Research Medical University
Автор, ответственный за переписку.
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 ul. Samory Mashela, Moscow, 117997; 1 ul. Ostrovityanova, Moscow, 117997
T. Trofimova
Department of Chemistry, M. V. Lomonosov Moscow State University; Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991; 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
N. Zolotova
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
I. Ivanov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
V. Spiridonov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
A. Proshin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Россия, 1 Severnyi proezd, Chernogolovka, Moscow Region, 142432
A. Borodkov
A. I. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences
Email: orlova.radiochem@mail.ru
Россия, 19 ul. Kosygina, Moscow, 119334
A. Yaroslavov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
A. Orlov
Department of Chemistry, M. V. Lomonosov Moscow State University
Email: orlova.radiochem@mail.ru
Россия, Build. 3, 1 Leninskie Gory, Moscow, 119991
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