Email this article Synthesis of γ-carbolines containing NO-donor fragment and assessment of their anticholinesterase activity
- Authors: Bachurin S.O.1, Ustinov A.K.1, Serkov I.V.1, Proshin A.N.1, Kovaleva N.V.1, Boltneva N.P.1, Makhaeva G.F.1
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Affiliations:
- Institute of Physiologically Active Compounds, Russian Academy of Sciences
- Issue: Vol 65, No 11 (2016)
- Pages: 2718-2721
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/239401
- DOI: https://doi.org/10.1007/s11172-016-1641-3
- ID: 239401
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Abstract
Hybrid γ-carboline-based compounds containing a nitrooxy group as an NO-donor were prepared. It was shown that the introduction of this group did not affect the inhibitory activity of γ-carboline pharmacophore against acetyl- and butyrylcholinesterase.
About the authors
S. O. Bachurin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
A. K. Ustinov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Author for correspondence.
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
I. V. Serkov
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
A. N. Proshin
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
N. V. Kovaleva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
N. P. Boltneva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
G. F. Makhaeva
Institute of Physiologically Active Compounds, Russian Academy of Sciences
Email: Ustinov_51@mail.ru
Russian Federation, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432
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