Synthesis of γ-carbolines containing NO-donor fragment and assessment of their anticholinesterase activity


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Hybrid γ-carboline-based compounds containing a nitrooxy group as an NO-donor were prepared. It was shown that the introduction of this group did not affect the inhibitory activity of γ-carboline pharmacophore against acetyl- and butyrylcholinesterase.

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S. Bachurin

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

A. Ustinov

Institute of Physiologically Active Compounds, Russian Academy of Sciences

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Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

I. Serkov

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

A. Proshin

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

N. Kovaleva

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

N. Boltneva

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

G. Makhaeva

Institute of Physiologically Active Compounds, Russian Academy of Sciences

Email: Ustinov_51@mail.ru
俄罗斯联邦, 1 Severny pr-d, Chernogolovka, Moscow Region, 142432

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