Email this article Effect of fluorinated tetrahydrocarbazole derivatives on the enzymes of oxidative deamination of biogenic amines and on the process of lipid peroxidation
- Authors: Nikolaeva N.S.1, Soldatova Y.V.2, Smolina A.V.2, Aksinenko A.Y.1, Sokolov V.B.2, Kinzirsky A.S.1, Kotel´nikova R.A.2, Shtolko V.N.2, Kotel´nikov A.I.2
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Affiliations:
- Institute of Physiologically Active Compounds of the Russian Academy of Sciences
- Institute of Problems of Chemical Physics of the Russian Academy of Sciences
- Issue: Vol 66, No 5 (2017)
- Pages: 870-874
- Section: Full Articles
- URL: https://journal-vniispk.ru/1066-5285/article/view/240573
- DOI: https://doi.org/10.1007/s11172-017-1821-9
- ID: 240573
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Abstract
The effect of two fluorinated derivatives of tetrahydrocarbazoles on mitochondrial en-zymes catalyzing the oxidative deamination of biogenic amines such as monoamine oxidase A and B (MAO-A and MAO-B) has been investigated. A dose-dependent effect of the studied compounds on the enzymatic activity MAO-A was shown. It was revealed that both com-pounds are MAO-B inhibitors. Inhibition mechanisms were established and MAO-B inhibi-tion constants were calculated. The above derivatives exhibit strong antioxidant and antirad-ical activity.
About the authors
N. S. Nikolaeva
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Author for correspondence.
Email: nikolaevans@bk.ru
Russian Federation, 1 Severny proezd, Chernogolovka, Moscow region, 142432
Yu. V. Soldatova
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
A. V. Smolina
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
A. Yu. Aksinenko
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 Severny proezd, Chernogolovka, Moscow region, 142432
V. B. Sokolov
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
A. S. Kinzirsky
Institute of Physiologically Active Compounds of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 Severny proezd, Chernogolovka, Moscow region, 142432
R. A. Kotel´nikova
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
V. N. Shtolko
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
A. I. Kotel´nikov
Institute of Problems of Chemical Physics of the Russian Academy of Sciences
Email: nikolaevans@bk.ru
Russian Federation, 1 prosp. Acad. Semenova, Chernogolovka, Moscow region, 142432
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