Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

A. A. Tumashov; D. A. Gruzdev; A. Yu. Vigorov; V. V. Musiyak; E. N. Chulakov; G. L. Levit; V. P. Krasnov; V. N. Charushin

doi:10.1007/s11172-018-2279-0

Analysis of racemic conjugates of purine with heterocyclic amines by chiral high-performance liquid chromatography

Authors: Tumashov A.A.¹^,2, Gruzdev D.A.¹, Vigorov A.Y.¹, Musiyak V.V.¹, Chulakov E.N.¹, Levit G.L.¹, Krasnov V.P.¹, Charushin V.N.¹^,3
Affiliations:
1. I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences
2. Institute of Natural Sciences and Mathematics, Ural Federal University
3. Institute of Chemical Engineering, Ural Federal University
Issue: Vol 67, No 9 (2018)
Pages: 1704-1709
Section: Article
URL: https://journal-vniispk.ru/1066-5285/article/view/243018
DOI: https://doi.org/10.1007/s11172-018-2279-0
ID: 243018

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Abstract

Reversed-phase HPLC on chiral stationary phases was used to study the influence of the structure of purine and 2-aminopurine conjugates with chiral heterocyclic amines on the retention times. The optimum conditions for separation of enantiomers were found. The best parameters of separation of stereoisomers of all the compounds examined were achieved on a (S,S)-Whelk-O1 column in weakly alkaline aqueous methanol systems.

About the authors

A. A. Tumashov

I. Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences; Institute of Natural Sciences and Mathematics, Ural Federal University

Email: izvan@ioc.ac.ru
Russian Federation, 22/20 ul. S. Kovalevskoi, Ekaterinburg, 620990; 19 ul. Mira, Ekaterinburg, 620002